⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9379728 | 0.87 | ROCK2 (0.31) | — | |
| SCHEMBL9380733 | 0.74 | AOC1 (0.32) | — | |
| SCHEMBL15791326 | 0.70 | AOC1 (0.37) | — | |
| SCHEMBL9381936 | 0.65 | MARK3 (0.32) | — | |
| SCHEMBL9380728 | 0.65 | CYP19A1 (0.30) | — | |
| SCHEMBL9377524 | 0.63 | GPBAR1 (0.32) | — | |
| SCHEMBL20621645 | 0.63 | AOC1 (0.40) | — | |
| SCHEMBL19186140 | 0.60 | AOC1 (0.41) | — | |
| SCHEMBL19186165 | 0.59 | AOC1 (0.43) | — | |
| SCHEMBL6910978 | 0.58 | AOC1 (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0413191-B1 | 1-(Pyridinylamino)-2-pyrrolidinones, a process for their preparation and their use as medicaments | HOECHST ROUSSEL PHARMA (US) | 1994-07-27 | — | — | EP | disclosed |
| EP-0413191-A1 | 1-(Pyridinylamino)-2-pyrrolidinones, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-02-20 | — | — | EP | disclosed |
| US-4994472-A | Cognition activators | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-02-19 | — | — | US | disclosed |