Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 5/20 | 0.74 |
| ▸ | DRD2 | P14416 | 5/20 | 0.74 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.74 |
| ▸ | DRD3 | P35462 | 5/20 | 0.74 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.74 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.74 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.74 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.74 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.74 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.74 |
| ▸ | LMNA | P02545 | 4/20 | 0.74 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.74 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.74 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.74 |
| ▸ | DRD1 | P21728 | 3/20 | 0.74 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.74 |
| ▸ | TSHR | P16473 | 2/20 | 0.74 |
| ▸ | PRNP | P04156 | 2/20 | 0.74 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.74 |
| ▸ | HRH1 | P35367 | 6/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4730313 | 0.89 | HTR1A (0.76) | HTR1ADRD2ADRA1ADRD3KCNH2 | |
| SCHEMBL24439565 | 0.89 | HRH1 (0.77) | HTR1ADRD2ADRA1ADRD3KCNH2 | |
| SCHEMBL29062451 | 0.88 | HTR1A (0.74) | HTR1ADRD2ADRA1ADRD3KCNH2 | |
| SCHEMBL7565495 | 0.86 | HRH1 (0.74) | HTR1ADRD2ADRA1ADRD3KCNH2 | |
| SCHEMBL9475738 | 0.86 | HTR1A (0.77) | HTR1ADRD2ADRA1ADRD3KCNH2 | |
| Acepromazine SCHEMBL73018 | 0.85 | CYP2D6 (1.00) | HTR1ADRD2ADRA1ADRD3KCNH2 | |
| Acepromazine SCHEMBL29441481 | 0.85 | CYP2D6 (1.00) | HTR1ADRD2ADRA1ADRD3KCNH2 | |
| Acepromazine SCHEMBL28142113 | 0.85 | CYP2D6 (1.00) | HTR1ADRD2ADRA1ADRD3KCNH2 | |
| Acepromazine SCHEMBL29582179 | 0.85 | CYP2D6 (1.00) | HTR1ADRD2ADRA1ADRD3KCNH2 | |
| SCHEMBL7566877 | 0.84 | HTR1A (0.70) | HTR1ADRD2ADRA1ADRD3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0414422-B1 | 2-Oxo-1-oxa-8-azaspiro [4,5] decane derivatives, processes for their preparation and pharmaceutical compositions thereof | RICHTER GEDEON VEGYESZET (HU) | 1994-04-06 | — | — | EP | disclosed |
| US-5157038-A | Antidepressants; tranquilizers; treatment of schizophrenia and epilepsy; antilepmic agents | RICHTER GEDEON VEGYESZETI GYAR RT. (HU) | 1992-10-20 | — | — | US | disclosed |
| EP-0414422-A2 | 2-Oxo-1-oxa-8-azaspiro [4,5] decane derivatives, processes for their preparation and pharmaceutical compositions thereof | RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) | 1991-02-27 | — | — | EP | disclosed |