Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.70 |
| ▸ | RAD52 | P43351 | 1/20 | 0.70 |
| ▸ | TLR8 | Q9NR97 | 6/20 | 0.56 |
| ▸ | CDK9 | P50750 | 1/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | RGS12 | O14924 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.46 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL939056 | 0.88 | TLR8 (0.56) | KDM4ERAD52TLR8CDK9DYRK1A | |
| SCHEMBL11442111 | 0.84 | KDM4E (0.71) | KDM4ERAD52TLR8HTTALDH1A1 | |
| SCHEMBL616998 | 0.84 | KDM4E (0.97) | KDM4ERAD52HTTALDH1A1CYP1A2 | |
| Hydrochloric Acid SCHEMBL16736724 | 0.83 | KDM4E (1.00) | KDM4ERAD52HTTALDH1A1CYP1A2 | |
| Hydrochloric Acid SCHEMBL6605580 | 0.83 | KDM4E (1.00) | KDM4ERAD52HTTALDH1A1CYP1A2 | |
| SCHEMBL24900472 | 0.81 | KDM4E (0.64) | KDM4ERAD52TLR8HTTALDH1A1 | |
| SCHEMBL30957519 | 0.81 | KDM4E (0.64) | KDM4ERAD52TLR8HTTALDH1A1 | |
| SCHEMBL29328857 | 0.79 | TDP1 (0.74) | KDM4ETLR8DYRK1AHTTALDH1A1 | |
| SCHEMBL1022300 | 0.78 | TLR8 (0.69) | TLR8HTTTSHRSMN1; SMN2TLR7 | |
| SCHEMBL22442338 | 0.77 | HCAR3 (0.59) | KDM4EHTTKMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110009448-A1 | Compound | STERIX LIMITED | 2011-01-13 | — | — | US | disclosed |
| US-7309715-B2 | Compound | STERIX LIMITED (GB) | 2007-12-18 | — | — | US | disclosed |
| US-20040143124-A1 | Compound | STERIX LIMITED (GB) | 2004-07-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110009448-A1 | Compound | NR4A1, GPR6, PRMT6 | KDM4E 565/4885RAD52 947/4885TLR8 1267/4885 |
| US-20040143124-A1 | Compound | NR4A1, CBR1, NR2C2 | KDM4E 893/4885RAD52 762/4885TLR8 1189/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.