Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | NQO2 | P16083 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9383828 | 0.85 | PTGDR (0.48) | LMNAKDM4EKMT2AMEN1CYP1A2 | |
| SCHEMBL9381350 | 0.81 | ALOX15 (0.55) | KDM4EALDH1A1MAPK1KMT2AMEN1 | |
| SCHEMBL9386614 | 0.79 | LMNA (0.47) | LMNAKDM4EALDH1A1KMT2ANQO2 | |
| SCHEMBL9383893 | 0.77 | PDGFRB (0.42) | LMNAKDM4EKMT2AMEN1CYP1A2 | |
| SCHEMBL2904873 | 0.76 | NQO2 (0.48) | KDM4ENQO2 | |
| SCHEMBL9379478 | 0.76 | KDM4E (0.46) | KDM4EALDH1A1HPGDTSHRHTT | |
| SCHEMBL5088534 | 0.72 | PLA2G2A (0.42) | LMNAKDM4EALDH1A1HPGDKMT2A | |
| SCHEMBL3330164 | 0.71 | KDM4E (0.56) | KDM4EPTGDR2 | |
| 2,4,5-Trichlorophenoxyacetic Acid, Methyl Ester SCHEMBL29561046 | 0.71 | LMNA (1.00) | LMNAKDM4EALDH1A1HPGDMAPK1 | |
| SCHEMBL2909922 | 0.69 | NQO2 (0.44) | KDM4EMAPK1KMT2ANQO2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0398283-B1 | Excitatory amino acid antagonists | MERRELL DOW PHARMA (US) | 1994-11-02 | — | — | EP | disclosed |
| US-5112821-A | Excitatory amino acid antagonists which are certain thienopyridives | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-05-12 | — | — | US | disclosed |
| US-5026700-A | Certain quinolines and thienopyridines as excitatory amino acid antagonists | MERRELL DOW PHARMACEUTICALS (US) | 1991-06-25 | — | — | US | disclosed |
| EP-0398283-A1 | Excitatory amino acid antagonists | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-11-22 | — | — | EP | disclosed |