Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 7/20 | 0.48 |
| ▸ | OPRD1 | P41143 | 5/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.48 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | DRD4 | P21917 | 1/20 | 0.45 |
| ▸ | OPRL1 | P41146 | 4/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28495176 | 0.86 | LMNA (0.42) | OPRM1OPRD1OPRK1SLC6A4OPRL1 | |
| SCHEMBL24691526 | 0.82 | OPRM1 (0.46) | OPRM1OPRD1OPRK1SLC22A1SLC6A4 | |
| SCHEMBL9378568 | 0.81 | OPRM1 (0.49) | OPRM1OPRD1OPRK1SLC22A1SLC6A4 | |
| SCHEMBL8234087 | 0.81 | SLC6A4 (0.46) | OPRM1OPRD1OPRK1SLC6A4OPRL1 | |
| SCHEMBL22479057 | 0.78 | OPRM1 (0.52) | OPRM1OPRD1OPRK1SLC22A1SLC6A4 | |
| SCHEMBL3377292 | 0.75 | LMNA (0.38) | OPRM1OPRD1OPRK1OPRL1LMNA | |
| SCHEMBL27699646 | 0.74 | OPRM1 (0.48) | OPRM1OPRD1OPRK1SLC22A1SLC6A4 | |
| SCHEMBL17888241 | 0.73 | OPRM1 (0.46) | OPRM1OPRD1OPRK1SLC22A1SLC6A4 | |
| SCHEMBL13849911 | 0.73 | OPRM1 (0.44) | OPRM1OPRD1OPRK1OPRL1LMNA | |
| SCHEMBL14402615 | 0.73 | OPRM1 (0.44) | OPRM1OPRD1OPRK1OPRL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0337167-B1 | 4-Aryl-4-piperidine (or pyrrolidine or hexahydroazepine) carbinols and heterocyclic analogs thereof | DU PONT MERCK PHARMA (US) | 1994-08-03 | — | — | EP | disclosed |
| US-5086063-A | Analgesics, antidepressants, anorexigenic agents | DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1992-02-04 | — | — | US | disclosed |
| US-5019650-A | 4-aryl-4-piperidine (or pyrrolidine or hexahydroazepine) carbinols and heterocyclic analogs thereof | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1991-05-28 | — | — | US | disclosed |
| EP-0337167-A1 | 4-Aryl-4-piperidine (or pyrrolidine or hexahydroazepine) carbinols and heterocyclic analogs thereof | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1989-10-18 | — | — | EP | disclosed |