Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.63 |
| ▸ | MAPT | P10636 | 4/20 | 0.63 |
| ▸ | NPC1 | O15118 | 4/20 | 0.63 |
| ▸ | RAB9A | P51151 | 4/20 | 0.63 |
| ▸ | CASP3 | P42574 | 1/20 | 0.63 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.63 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.63 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.63 |
| ▸ | KDR | P35968 | 2/20 | 0.59 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.56 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18762059 | 0.86 | KDM4E (0.55) | KDM4EMAPTNPC1RAB9ACASP3 | |
| SCHEMBL7196311 | 0.84 | ALDH1A1 (0.70) | KDM4EMAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL8987358 | 0.84 | ALDH1A1 (0.59) | KDM4EMAPTNPC1RAB9AKDR | |
| SCHEMBL29206326 | 0.83 | BRD4 (0.64) | KDM4EMAPTNPC1RAB9AKDR | |
| SCHEMBL2008746 | 0.82 | KDR (0.68) | KDM4ENPC1RAB9AKDRCHEK1 | |
| SCHEMBL29712353 | 0.82 | KDR (0.68) | KDM4ENPC1RAB9AKDRCHEK1 | |
| SCHEMBL5465099 | 0.81 | CDK5 (0.76) | KDM4EMAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL8925407 | 0.81 | CA1 (0.53) | PDGFRBFLT3 | |
| SCHEMBL11347026 | 0.80 | CDK5 (0.65) | KDM4EMAPTNPC1RAB9AKDR | |
| SCHEMBL30740090 | 0.80 | KDM4E (0.60) | KDM4EMAPTNPC1RAB9ACASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0620812-A1 | QUINOLONE DERIVATIVES | MERCK SHARP & DOHME LTD. (GB) | 1994-10-26 | — | — | EP | disclosed |
| WO-1993011115-A2 | QUINOLONE DERIVATIVES AND THEIR USE AS NMDA AND AMPA RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LIMITED (GB) | 1993-06-10 | — | — | WO | disclosed |
| US-4395414-A | Substituted quinolinone-alkanecarboxylic acids and medicaments containing them, having a hyperglycaemic action | BYK GULDEN LOMBERG CHEMISCHE FABRIK GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1983-07-26 | — | — | US | disclosed |
| EP-0024638-A1 | Substituted quinolinone-alkanecarboxylic acids, their preparation, and medicaments containing them | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1981-03-11 | — | — | EP | disclosed |
| WO-1981000564-A1 | SUBSTITUTED QUINOLINONE-ALKANECARBOXYLIC ACIDS,THEIR PREPARATION AND USE,AND MEDICAMENTS CONTAINING THEM | BYK GULDEN LOMBERG CHEM FAB (DE) | 1981-03-05 | — | — | WO | disclosed |