Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.60 |
| ▸ | KCNJ1 | P48048 | 6/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9384620 | 0.87 | KCNJ1 (0.64) | SIGMAR1KCNJ1KCNH2ABCC1 | |
| Hydrochloric Acid SCHEMBL9386222 | 0.86 | KCNJ1 (0.63) | SIGMAR1KCNJ1KCNH2ABCC1 | |
| SCHEMBL9385273 | 0.83 | HRH3 (0.60) | SIGMAR1KCNJ1KCNH2ALDH1A1MEN1 | |
| SCHEMBL9429643 | 0.82 | MEN1 (0.55) | SIGMAR1ALDH1A1MEN1KMT2AHTR1A | |
| SCHEMBL9388198 | 0.82 | LMNA (0.58) | SIGMAR1DRD2 | |
| SCHEMBL9428322 | 0.81 | SLC6A3 (0.57) | SIGMAR1KCNH2ALDH1A1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL9382887 | 0.81 | LMNA (0.57) | SIGMAR1DRD2HTR7 | |
| SCHEMBL9383628 | 0.81 | KCNJ1 (0.63) | SIGMAR1KCNJ1KCNH2ALDH1A1MEN1 | |
| Hydrochloric Acid SCHEMBL9428451 | 0.81 | MEN1 (0.54) | SIGMAR1ALDH1A1MEN1KMT2AHTR1A | |
| SCHEMBL9385849 | 0.81 | HTR1A (0.51) | KCNJ1KCNH2ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0369627-B1 | Pyrimidinedione derivative compounds, method of producing the same and antiarrythmic agents containing the same | MITSUI TOATSU CHEMICALS (JP) | 1994-12-21 | — | — | EP | disclosed |
| US-5008267-A | Pyrimidinedione compounds, method of producing the same and antiarrythmic agents containing the same | MITSUI TOATSU CHEMICALS, INCORPORATED (JP) | 1991-04-16 | — | — | US | disclosed |
| EP-0369627-A2 | Pyrimidinedione derivative compounds, method of producing the same and antiarrythmic agents containing the same | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1990-05-23 | — | — | EP | disclosed |