Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE2 | O96020 | 5/20 | 0.56 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.56 |
| ▸ | CDK2 | P24941 | 5/20 | 0.56 |
| ▸ | ELANE | P08246 | 2/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | METAP1 | P53582 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 3/20 | 0.41 |
| ▸ | CCND1 | P24385 | 3/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3119156 | 0.85 | GAA (0.57) | CCNE2CCNE1CDK2GAAALDH1A1 | |
| SCHEMBL29416441 | 0.85 | GAA (0.57) | CCNE2CCNE1CDK2GAAALDH1A1 | |
| SCHEMBL6683074 | 0.79 | CCNB2 (0.56) | CCNE2CCNE1CDK2MAOAMAOB | |
| SCHEMBL11803331 | 0.79 | MAOA (0.41) | CCNE2CCNE1CDK2MAOAMAOB | |
| SCHEMBL12070723 | 0.78 | MAOA (0.47) | CCNE2CCNE1CDK2ELANEMAOA | |
| SCHEMBL164157 | 0.76 | CCNE2 (0.41) | CCNE2CCNE1CDK2MAOAMAOB | |
| SCHEMBL9221476 | 0.73 | ALDH1A1 (0.83) | CCNE2CCNE1CDK2GAAALDH1A1 | |
| SCHEMBL162466 | 0.71 | METAP1 (0.38) | CCNE2CCNE1CDK2MAOAMAOB | |
| SCHEMBL24846161 | 0.70 | SMN1; SMN2 (0.51) | CCNE2CCNE1CDK2ALDH1A1MAPT | |
| SCHEMBL29389300 | 0.70 | MAOA (0.56) | MAOAMAOBGAAALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0612317-A1 | SUBSTITUTED HETEROCYCLES AS ANGIOTENSIN II ANTAGONISTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1994-08-31 | — | — | EP | disclosed |
| US-5256781-A | Anticholesterol, antilipemic, hypotensive agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-10-26 | — | — | US | disclosed |
| US-5236925-A | Hypotensive agents, treatment of congestive heart failure | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-08-17 | — | — | US | disclosed |
| WO-1993008170-A1 | SUBSTITUTED HETEROCYCLES AS ANGIOTENSIN II ANTAGONISTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-04-29 | — | — | WO | disclosed |
| US-5187168-A | Hypotensive agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-02-16 | — | — | US | disclosed |