Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | RXRA | P19793 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9385926 | 0.81 | KDM1A (0.37) | SIGMAR1KDM1AMAOAMAOBOPRM1 | |
| SCHEMBL9386634 | 0.74 | HSD11B1 (0.34) | HSD11B1SIGMAR1KDM1AMAOAMAOB | |
| SCHEMBL6849624 | 0.70 | PKM (0.49) | KDM1AMAOAMAOBOPRM1 | |
| SCHEMBL14449820 | 0.68 | KDM4E (0.36) | RXRAKDM4E | |
| SCHEMBL11220224 | 0.68 | MAPT (0.35) | SIGMAR1OPRM1LMNANPSR1 | |
| SCHEMBL15280340 | 0.67 | PKM (0.41) | SIGMAR1KDM1AMAOAMAOBKDM4E | |
| SCHEMBL14449323 | 0.67 | AKT1 (0.36) | KDM1AMAOAMAOBRXRAKDM4E | |
| SCHEMBL18165459 | 0.65 | GAA (0.36) | RXRAKDM4E | |
| SCHEMBL8669756 | 0.65 | HRH3 (0.43) | KDM1AOPRM1KDM4E | |
| SCHEMBL10434159 | 0.65 | KDM4E (0.37) | OPRM1RXRAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1994000450-A1 | CHROMANDERIVATIVES AS ANGIOTENSIN II ANTAGONISTS | ZENECA LIMITED (GB) | 1994-01-06 | — | — | WO | disclosed |