SCHEMBL9389232

SCHEMBL9389232

CC(C)(C)c1cc(CC=CC(=O)CO[PH](=O)OCC(=O)C=CCc2cc(C(C)(C)C)c(O)c(C(C)(C)C)c2)cc(C(C)(C)C)c1O

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.46
KMT2A Q03164 4/20 0.46
TSHR P16473 3/20 0.46
NPSR1 Q6W5P4 3/20 0.46
MAPK1 P28482 3/20 0.46
MEN1 O00255 3/20 0.46
CYP1A2 P05177 2/20 0.46
CYP3A4 P08684 2/20 0.46
BLM P54132 2/20 0.46
ATM Q13315 2/20 0.46
HIF1A Q16665 2/20 0.46
MAPT P10636 2/20 0.46
USP2 O75604 1/20 0.46
CYP2D6 P10635 1/20 0.46
GPR55 Q9Y2T6 1/20 0.39
GAA P10253 5/20 0.39
LMNA P02545 3/20 0.39
GABBR2 O75899 2/20 0.38
GABBR1 Q9UBS5 2/20 0.38
GMNN O75496 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6910731 0.82 GABBR2 (0.55) NPSR1CYP1A2GPR55GABBR2GABBR1
SCHEMBL6910725 0.82 GABBR2 (0.55) NPSR1CYP1A2GPR55GABBR2GABBR1
SCHEMBL6909702 0.80 MEN1 (0.42) ALDH1A1KMT2ATSHRNPSR1MAPK1
SCHEMBL11300873 0.78 ALDH1A1 (0.50) ALDH1A1KMT2ATSHRNPSR1MAPK1
SCHEMBL6910734 0.77 HMGCR (0.47) ALDH1A1KMT2ATSHRNPSR1MAPK1
SCHEMBL10724006 0.75 ALDH1A1 (0.57) ALDH1A1KMT2ATSHRNPSR1MAPK1
SCHEMBL8751538 0.75 ALDH1A1 (0.57) ALDH1A1KMT2ATSHRNPSR1MAPK1
SCHEMBL9225383 0.75 GAA (0.54) ALDH1A1KMT2ATSHRNPSR1MAPK1
SCHEMBL551093 0.75 ALDH1A1 (0.49) ALDH1A1KMT2ATSHRNPSR1MAPK1
SCHEMBL9394067 0.74 ALOX5 (0.49) ALDH1A1KMT2ANPSR1MAPK1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1994019358-A1 SUBSTITUTED PHOSPHONATES, THE PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM SYMPHAR S.A. (CH) 1994-09-01 WO claimed