Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ1 | P48048 | 15/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 14/20 | 0.60 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.46 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.46 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9389552 | 0.94 | KCNJ1 (0.59) | KCNJ1KCNH2HRH3SIGMAR1LMNA | |
| SCHEMBL9384677 | 0.84 | HRH3 (0.54) | HRH3LMNA | |
| SCHEMBL9428430 | 0.84 | SMN1; SMN2 (0.60) | KCNJ1KCNH2LMNA | |
| SCHEMBL9383407 | 0.83 | KCNJ1 (0.61) | KCNJ1KCNH2HRH3SIGMAR1ABCB1 | |
| SCHEMBL9384620 | 0.81 | KCNJ1 (0.64) | KCNJ1KCNH2HRH3SIGMAR1ABCB1 | |
| Hydrochloric Acid SCHEMBL9386222 | 0.80 | KCNJ1 (0.63) | KCNJ1KCNH2HRH3SIGMAR1ABCB1 | |
| SCHEMBL2731306 | 0.78 | KCNJ1 (1.00) | KCNJ1KCNH2HRH3SIGMAR1MAOA | |
| SCHEMBL9428657 | 0.77 | LMNA (0.51) | SIGMAR1LMNA | |
| SCHEMBL9385273 | 0.77 | HRH3 (0.60) | KCNJ1KCNH2HRH3SIGMAR1ABCB1 | |
| SCHEMBL10359671 | 0.75 | KCNJ1 (0.82) | KCNJ1KCNH2HRH3SIGMAR1MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0369627-B1 | Pyrimidinedione derivative compounds, method of producing the same and antiarrythmic agents containing the same | MITSUI TOATSU CHEMICALS (JP) | 1994-12-21 | — | — | EP | disclosed |
| US-5008267-A | Pyrimidinedione compounds, method of producing the same and antiarrythmic agents containing the same | MITSUI TOATSU CHEMICALS, INCORPORATED (JP) | 1991-04-16 | — | — | US | disclosed |
| EP-0369627-A2 | Pyrimidinedione derivative compounds, method of producing the same and antiarrythmic agents containing the same | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1990-05-23 | — | — | EP | disclosed |