Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9389285 | 0.84 | KCNJ1 (0.60) | LMNAKCNJ1KCNH2 | |
| SCHEMBL9428289 | 0.81 | HTR1A (0.49) | SMN1; SMN2HTR1AKCNJ1KCNH2ADRA1D | |
| SCHEMBL9428657 | 0.81 | LMNA (0.51) | SMN1; SMN2GAALMNAALDH1A1MAPT | |
| SCHEMBL9389552 | 0.78 | KCNJ1 (0.59) | LMNAALDH1A1KDM4EPKMKCNJ1 | |
| SCHEMBL9428545 | 0.72 | HTR1A (0.56) | SMN1; SMN2LMNAALDH1A1HSD17B10HTR1A | |
| SCHEMBL9429332 | 0.71 | DRD2 (0.53) | LMNAHTR1A | |
| SCHEMBL5745400 | 0.70 | KCNJ1 (0.61) | ALDH1A1KCNJ1KCNH2 | |
| SCHEMBL3715278 | 0.68 | KCNJ1 (0.58) | ALDH1A1MAPTPKMKCNJ1KCNH2 | |
| SCHEMBL11107794 | 0.68 | CYP2C9 (0.57) | ALDH1A1HTR1AKCNJ1KCNH2ADRA1D | |
| SCHEMBL9384677 | 0.68 | HRH3 (0.54) | SMN1; SMN2LMNAALDH1A1MAPTHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5332739-A | Pyrimidinedione derivatives and antiarrhythmic agents containing same | MITSUI TOATSU CHEMICALS, INCORPORATED (JP) | 1994-07-26 | — | — | US | disclosed |
| EP-0454498-A2 | Pyrimidinedione derivatives and antiarrhythmic agents containing same | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1991-10-30 | — | — | EP | disclosed |