Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOD1 | Q9Y239 | 5/20 | 1.00 |
| ▸ | TNF | P01375 | 2/20 | 1.00 |
| ▸ | NOD2 | Q9HC29 | 2/20 | 1.00 |
| ▸ | CXCL8 | P10145 | 2/20 | 1.00 |
| ▸ | SOS1 | Q07889 | 1/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.74 |
| ▸ | GALR3 | O60755 | 1/20 | 0.68 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.68 |
| ▸ | RAB9A | P51151 | 1/20 | 0.68 |
| ▸ | CSF1R | P07333 | 1/20 | 0.65 |
| ▸ | TSHR | P16473 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.58 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.58 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7165480 | 0.93 | TNF (0.87) | NOD1TNFNOD2CXCL8SOS1 | |
| SCHEMBL939417 | 0.88 | TNF (0.79) | NOD1TNFNOD2CXCL8SOS1 | |
| SCHEMBL9630558 | 0.86 | TNF (0.75) | NOD1TNFNOD2CXCL8SOS1 | |
| SCHEMBL4893740 | 0.85 | KMT2A (1.00) | NOD1TNFNOD2CXCL8SOS1 | |
| Hydrochloric Acid SCHEMBL11594488 | 0.84 | TNF (0.73) | NOD1TNFNOD2CXCL8SOS1 | |
| SCHEMBL7530572 | 0.84 | TNF (0.72) | NOD1TNFNOD2CXCL8SOS1 | |
| SCHEMBL11712432 | 0.84 | NOD1 (0.72) | NOD1TNFNOD2CXCL8SOS1 | |
| SCHEMBL4097969 | 0.83 | NOD1 (0.71) | NOD1TNFNOD2CXCL8SOS1 | |
| SCHEMBL14281041 | 0.83 | KMT2A (0.80) | NOD1TNFNOD2CXCL8SOS1 | |
| SCHEMBL7168102 | 0.82 | KMT2A (0.71) | NOD1TNFNOD2CXCL8SOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0545845-B1 | Imidazole compounds, their preparation and use as calcium channel blockers | NEUROSEARCH AS (DK) | 1996-02-28 | — | — | EP | claimed |
| US-5314903-A | Benzimidazole compounds useful as calcium channel blockers | NEUROSEARCH A/S (DK) | 1994-05-24 | — | — | US | claimed |
| EP-0545845-A1 | Imidazole compounds, their preparation and use as calcium channel blockers | NEUROSEARCH A/S (DK) | 1993-06-09 | — | — | EP | claimed |
| EP-2319512-A1 | Novel 2-amino benzimidazole derivatives and their use as modulators of small-conductance calcium-activated potassium channels. | NeuroSearch AS (DK) | 2011-05-11 | — | — | EP | disclosed |
| US-20110034527-A1 | NOVEL 2-AMINO BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS MODULATORS OF SMALL-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS | SOERENSEN ULRIK SVANE | 2011-02-10 | — | — | US | disclosed |
| US-7842817-B2 | 2-amino benzimidazole derivatives and their use as modulators of small-conductance calcium-activated potassium channels | NEUROSEARCH A/S (DK) | 2010-11-30 | — | — | US | disclosed |
| US-7842817-B2 | 2-amino benzimidazole derivatives and their use as modulators of small-conductance calcium-activated potassium channels | NEUROSEARCH A/S (DK) | 2010-11-30 | — | — | US | disclosed |
| EP-1838306-B1 | NOVEL 2-AMINO BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS MODULATORS OF SMALL-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS | NEUROSEARCH AS (DK) | 2010-11-17 | — | — | EP | disclosed |
| US-20100280087-A1 | NOVEL 2-AMINO BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS MODULATORS OF SMALL-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS | SOERENSEN ULRIK SVANE | 2010-11-04 | — | — | US | disclosed |
| US-20100280087-A1 | NOVEL 2-AMINO BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS MODULATORS OF SMALL-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS | SOERENSEN ULRIK SVANE | 2010-11-04 | — | — | US | disclosed |
| US-20080200529-A1 | Novel 2-Amino Benzimidazole Derivatives and Their Use As Modulators Of Small-Conductance Calcium-Activated Potassium Channels | NEURO SEARCH A/S (DK) | 2008-08-21 | — | — | US | disclosed |
| US-20080200529-A1 | Novel 2-Amino Benzimidazole Derivatives and Their Use As Modulators Of Small-Conductance Calcium-Activated Potassium Channels | NEURO SEARCH A/S (DK) | 2008-08-21 | — | — | US | disclosed |
| EP-0545845-B1 | Imidazole compounds, their preparation and use as calcium channel blockers | NEUROSEARCH AS (DK) | 1996-02-28 | — | — | EP | disclosed |
| US-5314903-A | Benzimidazole compounds useful as calcium channel blockers | NEUROSEARCH A/S (DK) | 1994-05-24 | — | — | US | disclosed |
| EP-0545845-A1 | Imidazole compounds, their preparation and use as calcium channel blockers | NEUROSEARCH A/S (DK) | 1993-06-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110034527-A1 | NOVEL 2-AMINO BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS MODULATORS OF SMALL-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS | KCNN2, KCNN1, KCNN3 | NOD1 964/4885TNF 4807/4885NOD2 784/4885 |
| US-20080200529-A1 | Novel 2-Amino Benzimidazole Derivatives and Their Use As Modulators Of Small-Conductance Calcium-Activated Potassium Channels | KCNN2, KCNN1, KCNN3 | NOD1 964/4885TNF 4807/4885NOD2 784/4885 |
| US-20100280087-A1 | NOVEL 2-AMINO BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS MODULATORS OF SMALL-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS | KCNN2, KCNN1, KCNN3 | NOD1 964/4885TNF 4807/4885NOD2 784/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.