Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 3/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.71 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.71 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.71 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.71 |
| ▸ | DPP4 | P27487 | 1/20 | 0.71 |
| ▸ | MEN1 | O00255 | 1/20 | 0.71 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.71 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.71 |
| ▸ | SLC28A2 | O43868 | 1/20 | 0.71 |
| ▸ | GAPDH | P04406 | 1/20 | 0.71 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.71 |
| ▸ | STAT6 | P42226 | 1/20 | 0.71 |
| ▸ | PI4KA | P42356 | 1/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.71 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.71 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.71 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.71 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.71 |
| ▸ | SLC28A3 | Q9HAS3 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6569310 | 0.92 | ADORA1 (0.73) | ADORA1SMN1; SMN2ADORA3ADORA2AADORA2B | |
| SCHEMBL8708990 | 0.91 | ADORA1 (0.71) | ADORA1SMN1; SMN2ADORA3ADORA2AADORA2B | |
| SCHEMBL1723484 | 0.88 | P2RY1 (0.70) | ADORA1SMN1; SMN2ADORA3ADORA2AADORA2B | |
| SCHEMBL12963362 | 0.87 | ADORA1 (0.76) | ADORA1SMN1; SMN2ADORA3ADORA2AADORA2B | |
| SCHEMBL5024895 | 0.87 | ADORA1 (0.76) | ADORA1SMN1; SMN2ADORA3ADORA2AADORA2B | |
| SCHEMBL2040670 | 0.87 | ADORA1 (0.76) | ADORA1SMN1; SMN2ADORA3ADORA2AADORA2B | |
| SCHEMBL10997946 | 0.87 | ADORA1 (0.76) | ADORA1SMN1; SMN2ADORA3ADORA2AADORA2B | |
| SCHEMBL481524 | 0.87 | ADORA1 (0.76) | ADORA1SMN1; SMN2ADORA3ADORA2AADORA2B | |
| SCHEMBL7803298 | 0.87 | ADORA1 (0.76) | ADORA1SMN1; SMN2ADORA3ADORA2AADORA2B | |
| SCHEMBL17440176 | 0.87 | ADORA1 (0.76) | ADORA1SMN1; SMN2ADORA3ADORA2AADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8609833-B2 | Purine derivatives as adenosine A1 receptor agonists and methods of use thereof | INOTEK PHARMACEUTICALS CORPORATION (US) | 2013-12-17 | — | — | US | disclosed |
| US-20120264706-A1 | PURINE DERIVATIVES AS ADENOSINE A1 RECEPTOR AGONISTS AND METHODS OF USE THEREOF | INOTEK PHARMACEUTICALS CORPORATION (US) | 2012-10-18 | — | — | US | disclosed |
| US-8183224-B2 | Purine derivatives as adenosine A1 receptor agonists and methods of use thereof | INOTEK PHARMACEUTICALS CORPORATION (US) | 2012-05-22 | — | — | US | disclosed |
| US-20110002843-A1 | METHOD OF DETECTING MYOCARDIAL DYSFUNCTION IN PATIENTS HAVING A HISTORY OF ASTHMA OR BRONCHOSPASM | BARRETT RICHARD J | 2011-01-06 | — | — | US | disclosed |
| EP-1758596-B9 | PURINE DERIVATIVES AS ADENOSINE A1 RECEPTOR AGONISTS AND METHODS OF USE THEREOF | INOTEK PHARMACEUTICALS CORP (US) | 2010-09-15 | — | — | EP | disclosed |
| EP-2221307-A1 | Purine derivatives as adenosine A1 receptor agonists and methods of use thereof | Inotek Pharmaceuticals Corporation (US) | 2010-08-25 | — | — | EP | disclosed |
| EP-1758596-B1 | PURINE DERIVATIVES AS ADENOSINE A1 RECEPTOR AGONISTS AND METHODS OF USE THEREOF | INOTEK PHARMACEUTICALS CORP (US) | 2010-03-31 | — | — | EP | disclosed |
| US-7655637-B2 | N-pyrazole A2A receptor agonists | GILEAD PALO ALTO, INC. (US) | 2010-02-02 | — | — | US | disclosed |
| US-20090062314-A1 | Purine derivatives as adenosine A1 receptor agonists and methods of use thereof | INOTEK PHARMACEUTICALS CORPORATION (US) | 2009-03-05 | — | — | US | disclosed |
| US-7423144-B2 | Purine Derivatives as adenosine A1 receptor agonists and methods of use thereof | INOTEK PHARMACEUTICALS CORPORATION (US) | 2008-09-09 | — | — | US | disclosed |
| US-6368573-B1 | MEASURING MYOCARDIAL FUNCTION IN MAMMAL | KING PHARMACEUTICALS RESEARCH AND DEVELOPMENT, INC. | 2002-04-09 | — | — | US | disclosed |
| EP-0727959-A4 | DIAGNOSTIC USES OF HYDRAZINOADENOSINES | DISCOVERY THERAPEUTICS INC (US) | 2000-11-08 | — | — | EP | disclosed |
| EP-0727959-A4 | DIAGNOSTIC USES OF HYDRAZINOADENOSINES | DISCOVERY THERAPEUTICS INC (US) | 2000-11-08 | — | — | EP | disclosed |
| EP-0727959-A1 | DIAGNOSTIC USES OF HYDRAZINOADENOSINES | Discovery Therapeutics, Inc. (US) | 1996-08-28 | — | — | EP | disclosed |
| EP-0727959-A1 | DIAGNOSTIC USES OF HYDRAZINOADENOSINES | Discovery Therapeutics, Inc. (US) | 1996-08-28 | — | — | EP | disclosed |
| US-5477857-A | Measuring myocardial function in mammals | DISCOVERY THERAPEUTICS, INC. (US) | 1995-12-26 | — | — | US | disclosed |
| US-5477857-A | Measuring myocardial function in mammals | DISCOVERY THERAPEUTICS, INC. (US) | 1995-12-26 | — | — | US | disclosed |
| US-5477857-A | Measuring myocardial function in mammals | DISCOVERY THERAPEUTICS, INC. (US) | 1995-12-26 | — | — | US | disclosed |
| WO-1995007049-A1 | DIAGNOSTIC USES OF HYDRAZINOADENOSINES | DISCOVERY THERAPEUTICS, INC. (US) | 1995-03-16 | — | — | WO | disclosed |
| WO-1995007049-A1 | DIAGNOSTIC USES OF HYDRAZINOADENOSINES | DISCOVERY THERAPEUTICS, INC. (US) | 1995-03-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110002843-A1 | METHOD OF DETECTING MYOCARDIAL DYSFUNCTION IN PATIENTS HAVING A HISTORY OF ASTHMA OR BRONCHOSPASM | TNNI3, BDKRB2, BDKRB1 | ADORA1 362/4885SMN1; SMN2 4154/4885ADORA3 159/4885 |
| US-20090062314-A1 | Purine derivatives as adenosine A1 receptor agonists and methods of use thereof | ADORA2A, ADORA1, ADORA3 | ADORA1 2/4885SMN1; SMN2 886/4885ADORA3 3/4885 |
| US-20120264706-A1 | PURINE DERIVATIVES AS ADENOSINE A1 RECEPTOR AGONISTS AND METHODS OF USE THEREOF | ADORA2A, ADORA1, ADORA3 | ADORA1 2/4885SMN1; SMN2 886/4885ADORA3 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.