Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diethylamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | KCNK3 | O14649 | 3/20 | 0.36 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.35 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diethylamine SCHEMBL7761030 | 0.94 | MEN1 (0.36) | POLBKCNK3KCNK9L3MBTL1NPC1 | |
| Diethylamine SCHEMBL9233068 | 0.89 | RAB9A (0.38) | POLBL3MBTL1NPC1RAB9ASMN1; SMN2 | |
| Diethylamine SCHEMBL9400426 | 0.89 | RAB9A (0.39) | POLBKCNK3KCNK9L3MBTL1NPC1 | |
| Diethylamine SCHEMBL7760658 | 0.88 | HSD17B10 (0.40) | POLBKCNK3KCNK9NPC1RAB9A | |
| Diethylamine SCHEMBL9400506 | 0.88 | MEN1 (0.37) | POLBKCNK3KCNK9NPC1RAB9A | |
| Diethylamine SCHEMBL9400383 | 0.88 | LMNA (0.39) | POLBKCNK3NPC1RAB9ASMN1; SMN2 | |
| Diethylamine SCHEMBL9400385 | 0.88 | KDM4E (0.41) | POLBKCNK3KCNK9L3MBTL1NPC1 | |
| SCHEMBL9400401 | 0.86 | MAPT (0.44) | L3MBTL1NPC1RAB9ASMN1; SMN2MAPT | |
| Diethylamine SCHEMBL9400455 | 0.86 | KCNK9 (0.43) | POLBKCNK9NPC1RAB9ASMN1; SMN2 | |
| Diethylamine SCHEMBL9400442 | 0.86 | KCNK9 (0.43) | POLBKCNK3KCNK9L3MBTL1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5372917-A | Excellent color forming property, storage stability and recorded image preservability; pyrazolone derivatives | KANZAKI PAPER MANUFACTURING CO., LTD. (JP) | 1994-12-13 | — | — | US | disclosed |