Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diethylamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 3/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dimethylamine SCHEMBL9400409 | 0.91 | SMN1; SMN2 (0.42) | HSD17B10SMN1; SMN2LMNAPKMHTT | |
| Diethylamine SCHEMBL7761090 | 0.89 | SMN1; SMN2 (0.41) | HSD17B10SMN1; SMN2LMNAPKMHTT | |
| Diethylamine SCHEMBL7760670 | 0.88 | HSD17B10 (0.35) | HSD17B10SMN1; SMN2LMNAPKMHTT | |
| Diethylamine SCHEMBL9400404 | 0.88 | POLB (0.37) | HSD17B10SMN1; SMN2LMNAHTTPOLB | |
| Diethylamine SCHEMBL7759226 | 0.86 | HSD17B10 (0.34) | HSD17B10LMNAPKMHTTPOLB | |
| Diethylamine SCHEMBL7759284 | 0.86 | GRM5 (0.38) | LMNAHTTPOLBHDAC8HDAC6 | |
| SCHEMBL7760648 | 0.85 | CNR2 (0.43) | SMN1; SMN2LMNAALDH1A1NPC1MAPT | |
| SCHEMBL9400406 | 0.83 | KCNK3 (0.42) | SMN1; SMN2LMNAPKMHTTHDAC8 | |
| Diethylamine SCHEMBL7761030 | 0.82 | MEN1 (0.36) | SMN1; SMN2LMNAHTTPOLBGAA | |
| Diethylamine SCHEMBL7756020 | 0.80 | L3MBTL1 (0.39) | SMN1; SMN2HTTHDAC8HDAC6GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0665462-B1 | Thermofixable photosensitive recording material and process for preparing thereof | NEW OJI PAPER CO LTD (JP) | 2001-04-18 | — | — | EP | disclosed |
| US-5565306-A | SUBSTRATE HAVING RECORDING LAYER CONTAINING PYRAZOLONE DERIVATIVE, HYDROQUINONE DERIVATIVE, ACIDIC SUBSTANCE MUTUALLY DISSOLVED THEREIN | NEW OJI PAPER CO., LTD. (JP) | 1996-10-15 | — | — | US | disclosed |
| EP-0665462-A1 | Thermofixable photosensitive recording material and process for preparing thereof | NEW OJI PAPER CO., LTD. (JP) | 1995-08-02 | — | — | EP | disclosed |
| US-5372917-A | Excellent color forming property, storage stability and recorded image preservability; pyrazolone derivatives | KANZAKI PAPER MANUFACTURING CO., LTD. (JP) | 1994-12-13 | — | — | US | disclosed |