Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 8/20 | 0.54 |
| ▸ | DRD2 | P14416 | 5/20 | 0.54 |
| ▸ | HTR2A | P28223 | 5/20 | 0.54 |
| ▸ | DRD3 | P35462 | 4/20 | 0.54 |
| ▸ | DRD1 | P21728 | 3/20 | 0.54 |
| ▸ | DRD5 | P21918 | 2/20 | 0.54 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.50 |
| ▸ | DRD4 | P21917 | 1/20 | 0.50 |
| ▸ | HTR2C | P28335 | 1/20 | 0.50 |
| ▸ | HRH1 | P35367 | 1/20 | 0.50 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9056742 | 0.85 | HTR1A (0.56) | HTR1ADRD2HTR2ADRD3ADRA2C | |
| SCHEMBL9401056 | 0.83 | HTR1A (0.53) | HTR1ADRD2HTR2ADRD3ADRA2C | |
| SCHEMBL9400862 | 0.75 | TSHR (0.57) | HTR1ADRD2HTR2ADRD3DRD1 | |
| SCHEMBL9401001 | 0.74 | KAT2A (0.48) | HTR1ASIGMAR1 | |
| SCHEMBL10567988 | 0.74 | MPI (0.49) | — | |
| SCHEMBL9401064 | 0.73 | DRD2 (0.48) | HTR1ADRD2HTR2ADRD3DRD5 | |
| SCHEMBL9400970 | 0.73 | TSHR (0.55) | HTR1ADRD2HTR2ADRD3DRD1 | |
| SCHEMBL9401043 | 0.73 | HTR1A (0.52) | HTR1ADRD2HTR2ADRD3DRD1 | |
| SCHEMBL17948287 | 0.72 | P4HB (0.57) | HTR1ADRD2DRD3ADRA2CDRD4 | |
| SCHEMBL23302566 | 0.71 | PARP1 (0.54) | HTR1ADRD2HTR2ADRD3DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5314884-A | Antidepressants, anxiolytic agents | TROPONWERKE GMBH & CO. (DE) | 1994-05-24 | — | — | US | disclosed |