SCHEMBL9401258

SCHEMBL9401258

COc1cc(OC)nc(SC(C=O)Cc2ccc(C(C)(C)C)cc2)n1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TP53 P04637 1/20 0.46
TSHR P16473 1/20 0.46
COPS5 Q92905 1/20 0.34
CYP1A2 P05177 1/20 0.34
CYP2E1 P05181 1/20 0.34
CYP3A4 P08684 1/20 0.34
CYP2C8 P10632 1/20 0.34
CYP2D6 P10635 1/20 0.34
CYP2C9 P11712 1/20 0.34
CYP2B6 P20813 1/20 0.34
CYP2C19 P33261 1/20 0.34
EDNRB P24530 1/20 0.34
EDNRA P25101 1/20 0.34
ALOX5 P09917 2/20 0.33
PTGES O14684 1/20 0.33
PPARG P37231 1/20 0.33
SCN5A Q14524 1/20 0.32
GRIN2C Q14957 1/20 0.32
SCN9A Q15858 1/20 0.32
MEN1 O00255 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9401327 0.86 ALOX5 (0.43) CYP1A2CYP2D6CYP2C19ALOX5MEN1
SCHEMBL9401522 0.85 EDNRB (0.36) CYP1A2CYP2D6CYP2C9CYP2C19EDNRB
SCHEMBL9384583 0.85 PTGES (0.42) ALOX5PTGESPPARG
SCHEMBL9401551 0.79 COPS5 (0.35) TP53TSHRCOPS5CYP1A2CYP2E1
SCHEMBL9401285 0.79 ALDH1A1 (0.35) CYP1A2EDNRBEDNRALMNAALDH1A1
SCHEMBL9401343 0.79 TP53 (0.33) TP53TSHRCYP1A2EDNRBEDNRA
SCHEMBL9383531 0.76 ALDH1A1 (0.37) ALOX5PTGESPPARGLMNAALDH1A1
SCHEMBL9401344 0.75 CTSA (0.34) EDNRBEDNRAALOX5PTGESPPARG
SCHEMBL9401540 0.74 PTGES (0.33) ALOX5PTGESPPARGSCN5A
SCHEMBL9401493 0.74 CTSA (0.36) EDNRBEDNRAALOX5PTGESPPARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5346880-A Pre- and postemergence NIHON BAYER AGROCHEM K.K. (JP) 1994-09-13 US disclosed
EP-0565951-A1 Herbicidally active pyrimidinylthioalkane derivatives NIHON BAYER AGROCHEM K.K. (JP) 1993-10-20 EP disclosed