Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 5/20 | 0.67 |
| ▸ | CYP11B1 | P15538 | 10/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 10/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9401596 | 0.84 | TBXAS1 (0.67) | TBXAS1CYP11B1CYP11B2KDM4EALDH1A1 | |
| Imitrodast SCHEMBL166460 | 0.80 | TBXAS1 (1.00) | TBXAS1 | |
| Imitrodast SCHEMBL99497 | 0.79 | TBXAS1 (0.98) | TBXAS1 | |
| Imitrodast SCHEMBL8156405 | 0.79 | TBXAS1 (0.81) | TBXAS1CYP11B1CYP11B2CYP19A1KDM4E | |
| SCHEMBL9836779 | 0.79 | TBXAS1 (0.76) | TBXAS1CYP19A1KDM4E | |
| SCHEMBL9836523 | 0.77 | TBXAS1 (0.74) | TBXAS1CYP11B1CYP11B2 | |
| SCHEMBL8068167 | 0.75 | TBXAS1 (0.64) | TBXAS1KDM4EALDH1A1MAPK1HSD17B10 | |
| SCHEMBL9835155 | 0.69 | TBXAS1 (0.79) | TBXAS1ALDH1A1 | |
| SCHEMBL9835184 | 0.68 | TBXAS1 (0.61) | TBXAS1KDM4EALDH1A1MAPK1HSD17B10 | |
| SCHEMBL9837297 | 0.68 | TBXAS1 (0.64) | TBXAS1CYP19A1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5286869-A | Vasodilators and anticoagulants | FUJIREBIO KABUSHIKI KAISHA (JP) | 1994-02-15 | — | — | US | disclosed |
| EP-0403957-A2 | Optical active 1,4-dihydropyridine derivates | FUJIREBIO INC. (JP) | 1990-12-27 | — | — | EP | disclosed |