Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | HMGCR | P04035 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | PPARD | Q03181 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12440450 | 0.84 | TSHR (0.40) | TSHRHMGCRTP53TDP1POLB | |
| SCHEMBL12440389 | 0.80 | TSHR (0.37) | TSHRHMGCRTP53TDP1POLB | |
| SCHEMBL9652021 | 0.77 | TSHR (0.48) | TSHRHMGCRTP53TDP1POLB | |
| SCHEMBL14010277 | 0.77 | LMNA (0.36) | CYP2C19LMNA | |
| SCHEMBL12876228 | 0.74 | PPARD (0.36) | TSHRTP53TDP1PPARDCA12 | |
| SCHEMBL7644740 | 0.73 | TSHR (0.43) | TSHRHMGCRTP53TDP1POLB | |
| SCHEMBL19468552 | 0.73 | TSHR (0.43) | TSHRHMGCRTP53TDP1POLB | |
| SCHEMBL9063886 | 0.73 | PPARD (0.44) | TSHRHMGCRTP53TDP1POLB | |
| SCHEMBL1852177 | 0.73 | TSHR (0.39) | TSHRHMGCRTP53TDP1POLB | |
| SCHEMBL1850109 | 0.73 | AOX1 (0.40) | TSHRHMGCRTP53TDP1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9320803-B2 | Bisphosphonate-prodrugs | KTB TUMORFORSCHUNGSGESELLSCHAFT MBH (DE) | 2016-04-26 | — | — | US | disclosed |
| US-9320803-B2 | Bisphosphonate-prodrugs | KTB TUMORFORSCHUNGSGESELLSCHAFT MBH (DE) | 2016-04-26 | — | — | US | disclosed |
| US-20140051623-A1 | Bisphosphonate-Prodrugs | KTB TUMORFORSCHUNGSGESELLSCHAFT MBH (DE) | 2014-02-20 | — | — | US | disclosed |
| US-20140051623-A1 | Bisphosphonate-Prodrugs | KTB TUMORFORSCHUNGSGESELLSCHAFT MBH (DE) | 2014-02-20 | — | — | US | disclosed |
| US-5300604-A | Functionalizing styrene-tyrep polymers with bisphosphonic acid derivatives and crosslinkers | NAESMAN JAN ANDERS H (FI) | 1994-04-05 | — | — | US | disclosed |
| US-5200554-A | Macroporous styrene copolymers; crosslinking, durability | NASMAN JAN ANDERS H (US) | 1993-04-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140051623-A1 | Bisphosphonate-Prodrugs | BPGM, PIK3CA, PPA1 | TSHR 2948/4885HMGCR 2300/4885TP53 519/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.