Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 2/20 | 0.32 |
| ▸ | MAOB | P27338 | 2/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9404436 | 0.79 | MAOA (0.31) | MAOAMAOB | |
| SCHEMBL9498998 | 0.63 | CHRM2 (0.56) | CHRM2CHRM5CHRM1 | |
| SCHEMBL12043297 | 0.63 | CHRM2 (0.56) | CHRM2CHRM5CHRM1 | |
| Milameline SCHEMBL8730187 | 0.62 | CHRM2 (0.97) | CHRM2CHRM5CHRM1 | |
| Milameline SCHEMBL5819625 | 0.62 | CHRM2 (0.97) | CHRM2CHRM5CHRM1 | |
| SCHEMBL12867629 | 0.62 | ADRA2A (0.33) | MAOAMAOB | |
| SCHEMBL19243978 | 0.61 | ALDH1A1 (0.34) | MAOAMAOBSLC6A4 | |
| SCHEMBL21323127 | 0.59 | MEN1 (0.37) | CHRM2CHRM5MAOAMAOB | |
| SCHEMBL18600363 | 0.59 | — | — | |
| SCHEMBL6453856 | 0.59 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0316718-B1 | AZACYCLIC COMPOUNDS AND THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1993-09-15 | — | — | EP | claimed |
| US-5356912-A | 3-(5-isoxazolyl)-1-methyl-1,2,3,6-tetrahydropyridine useful for treating Alzheimer's disease | NOVO NORDISK A/S (DK) | 1994-10-18 | — | — | US | disclosed |
| US-5262427-A | Cognition activators for Alzheimer*s disease | NOVO NORDISK A/S (DK) | 1993-11-16 | — | — | US | disclosed |
| EP-0316718-B1 | AZACYCLIC COMPOUNDS AND THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1993-09-15 | — | — | EP | disclosed |