Sugi Predict

Sugi Predict / Compounds / SCHEMBL9404436

SCHEMBL9404436

SCHEMBL9404436

CN1CCC(Cl)=C(C=NO)C1

nearest known ligand 0.33

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ MAOA P21397 1/20 0.31
▸ MAOB P27338 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9404401 0.79 CHRM2 (0.46) MAOAMAOB
SCHEMBL9404405 0.79 CHRM2 (0.46) MAOAMAOB
SCHEMBL9625300 0.67 FAAH (0.46) —
SCHEMBL12867629 0.64 ADRA2A (0.33) MAOAMAOB
SCHEMBL19243978 0.63 ALDH1A1 (0.34) MAOAMAOB
SCHEMBL21323127 0.62 MEN1 (0.37) MAOAMAOB
SCHEMBL16686670 0.61 MAOA (0.49) MAOAMAOB
SCHEMBL16686672 0.61 MAOA (0.49) MAOAMAOB
SCHEMBL9009633 0.60 CHRM2 (0.64) —
SCHEMBL9009653 0.60 CHRM2 (0.64) —

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0316718-B1 AZACYCLIC COMPOUNDS AND THEIR PREPARATION AND USE NOVO NORDISK A/S (DK) 1993-09-15 — — EP claimed
US-5356912-A 3-(5-isoxazolyl)-1-methyl-1,2,3,6-tetrahydropyridine useful for treating Alzheimer's disease NOVO NORDISK A/S (DK) 1994-10-18 — — US disclosed
US-5262427-A Cognition activators for Alzheimer*s disease NOVO NORDISK A/S (DK) 1993-11-16 — — US disclosed
EP-0316718-B1 AZACYCLIC COMPOUNDS AND THEIR PREPARATION AND USE NOVO NORDISK A/S (DK) 1993-09-15 — — EP disclosed
EP-0316718-A2 Azacyclic compounds and their preparation and use NOVO NORDISK A/S (DK) 1989-05-24 — — EP disclosed