Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.34 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.33 |
| ▸ | MTOR | P42345 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | CNR2 | P34972 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9429534 | 0.90 | SCN3A (0.34) | OPRK1TSHRHTR4LMNACNR2 | |
| SCHEMBL9404548 | 0.90 | HRH4 (0.39) | CYP1A2CYP3A4TSHRCYP2C19CYP2D6 | |
| SCHEMBL9404451 | 0.88 | OPRK1 (0.37) | OPRK1POLBUSP30HTR4KDM4E | |
| SCHEMBL7329892 | 0.86 | KDM4E (0.39) | OPRK1POLBUSP30HTR4PIK3CA | |
| SCHEMBL9430270 | 0.86 | OPRK1 (0.41) | OPRK1POLBUSP30HTR4LMNA | |
| SCHEMBL9404293 | 0.86 | USP30 (0.38) | OPRK1POLBCYP2D6USP30HTR4 | |
| SCHEMBL7321007 | 0.83 | HTR4 (0.43) | OPRK1POLBCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL9430240 | 0.79 | HRH4 (0.39) | OPRK1CYP2D6HTR4CNR2 | |
| SCHEMBL9404271 | 0.79 | OPRK1 (0.38) | OPRK1USP30HTR4 | |
| SCHEMBL9404530 | 0.79 | PDE4A (0.36) | OPRK1POLBCYP2D6HTR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5371080-A | Central nervous system disorders | NOVO NORDISK A/S | 1994-12-06 | — | — | US | disclosed |
| EP-0619820-A1 | IMIDAZOQUINAZOLINE COMPOUNDS AND THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1994-10-19 | — | — | EP | disclosed |
| WO-1993013103-A1 | IMIDAZOQUINAZOLINE COMPOUNDS AND THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1993-07-08 | — | — | WO | disclosed |