Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | TERT | O14746 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | LTK | P29376 | 1/20 | 0.38 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | RAD52 | P43351 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9404911 | 0.85 | TERT (0.35) | KCNH2ALDH1A1NFKB1TERTPOLB | |
| SCHEMBL9404893 | 0.84 | SMN1; SMN2 (0.38) | TERTPOLBSMN1; SMN2HRH3HIF1A | |
| SCHEMBL7657838 | 0.78 | ALDH1A1 (0.38) | ALDH1A1POLBSMN1; SMN2MAPTKMT2A | |
| SCHEMBL9404925 | 0.76 | POLB (0.41) | ALDH1A1POLBSMN1; SMN2MAPTRAB9A | |
| SCHEMBL7664272 | 0.76 | ALDH1A1 (0.39) | ALDH1A1POLBCYP3A4MAPTKMT2A | |
| SCHEMBL7653076 | 0.75 | HDAC1 (0.38) | ALDH1A1POLBMAPTKMT2ARAB9A | |
| SCHEMBL9404891 | 0.75 | TSHR (0.36) | MAOA | |
| SCHEMBL9404931 | 0.75 | MAOA (0.33) | ALDH1A1POLBTHRBMAPTRAB9A | |
| SCHEMBL9404941 | 0.73 | ALDH1A1 (0.43) | ALDH1A1POLBSMN1; SMN2KMT2ARAB9A | |
| SCHEMBL9404879 | 0.72 | ALDH1A1 (0.36) | ALDH1A1POLBMAPTKMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0296597-B1 | Hexa-cyclic compound | DAIICHI SEIYAKU CO (JP) | 1994-09-21 | — | — | EP | disclosed |
| US-5061795-A | ANTITUMOR AGENTS | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1991-10-29 | — | — | US | disclosed |
| US-4939255-A | Hexa-cyclic camptothecin derivatives | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1990-07-03 | — | — | US | disclosed |