Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TRIM24 | O15164 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29187823 | 0.81 | NOTUM (0.47) | NOTUMTP53NR3C1PDE4APDE4B | |
| SCHEMBL10689216 | 0.75 | HTR2A (0.39) | NOTUM | |
| SCHEMBL10689206 | 0.73 | NOTUM (0.40) | NOTUMTP53NR3C1PDE4APDE4B | |
| SCHEMBL10689213 | 0.72 | NOTUM (0.39) | NOTUMTP53NR3C1LMNAPOLB | |
| N-Benzylmethylamine SCHEMBL10694644 | 0.68 | ALDH1A1 (0.37) | NOTUMTP53PDE4APDE4BPDE4C | |
| SCHEMBL718605 | 0.68 | NOTUM (0.53) | NOTUMTP53NR3C1PDE4APDE4B | |
| SCHEMBL30573244 | 0.68 | NOTUM (0.53) | NOTUMTP53NR3C1PDE4APDE4B | |
| SCHEMBL10694640 | 0.66 | ALDH1A1 (0.44) | TP53LMNAPOLBALDH1A1MEN1 | |
| SCHEMBL6273537 | 0.65 | NOTUM (0.57) | NOTUMLMNAHSD17B10ALDH1A1MEN1 | |
| SCHEMBL9404866 | 0.65 | LMNA (0.47) | NOTUMPDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4792559-A | 1,2,3,4-tetrahydroquinoline substituted 5-aminopentanenitrile compounds and their use as calcium modulators | ADIR ET COMPAGNIE (FR) | 1988-12-20 | — | — | US | disclosed |