SCHEMBL940549

SCHEMBL940549

Cc1c(O[SiH3])ccc(-c2ccccc2)c1C

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CD274 Q9NZQ7 4/20 0.40
PDCD1 Q15116 1/20 0.40
ESR2 Q92731 1/20 0.37
PARP10 Q53GL7 1/20 0.37
PARP11 Q9NR21 1/20 0.37
SQOR Q9Y6N5 1/20 0.36
PTGDR2 Q9Y5Y4 1/20 0.36
CYP2A6 P11509 1/20 0.35
CYP2B6 P20813 1/20 0.35
AKT1 P31749 1/20 0.33
AKT2 P31751 1/20 0.33
BACE1 P56817 2/20 0.33
HTR7 P34969 1/20 0.33
ALOX5 P09917 1/20 0.32
TP53 P04637 1/20 0.32
MAPT P10636 1/20 0.32
PDE4B Q07343 2/20 0.32
PDE4A P27815 1/20 0.32
PDE4C Q08493 1/20 0.32
PDE4D Q08499 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24747126 0.82 SQOR (0.44) CD274PDCD1SQORCYP2A6CYP2B6
SCHEMBL9792869 0.80 PDCD1 (0.54) CD274PDCD1ESR2PARP10PARP11
SCHEMBL27397264 0.74 NPC1 (0.46) SQORTP53MAPTPDE4BPDE4A
SCHEMBL705576 0.73 LMNA (0.34) ESR2PTGDR2CYP2A6BACE1ALOX5
SCHEMBL10534592 0.73 INPPL1 (0.48) CD274PDCD1ESR2PARP10PARP11
SCHEMBL13377972 0.72 NPC1 (0.48) CD274PDCD1ESR2PARP10PARP11
SCHEMBL2400343 0.72 ESR2 (0.48) CD274PDCD1ESR2PARP10PARP11
SCHEMBL30804714 0.72 ESR2 (0.48) CD274PDCD1ESR2PARP10PARP11
SCHEMBL714015 0.72 MAPK1 (0.48) CYP2A6HTR7TP53KDM4EALDH1A1
SCHEMBL13744810 0.71 TP53 (0.51) SQORTP53MAPTPDE4BPDE4A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110009582-A1 Preparation of Activating Supports TOTAL PETROCHEMICALS RESEARCH FELUY (BE) 2011-01-13 US claimed
EP-2170511-A1 PREPARATION OF ACTIVATING SUPPORTS Total Petrochemicals Research Feluy (BE) 2010-04-07 EP claimed
WO-2009013197-A1 PREPARATION OF ACTIVATING SUPPORTS TOTAL PETROCHEMICALS RESEARCH FELUY (BE) 2009-01-29 WO claimed
US-8394737-B2 Preparation of activating supports TOTAL PETROCHEMICALS RESEARCH FELUY Seneffe (BE) 2013-03-12 US disclosed
US-20110009582-A1 Preparation of Activating Supports TOTAL PETROCHEMICALS RESEARCH FELUY (BE) 2011-01-13 US disclosed
EP-2170511-A1 PREPARATION OF ACTIVATING SUPPORTS Total Petrochemicals Research Feluy (BE) 2010-04-07 EP disclosed
WO-2009013197-A1 PREPARATION OF ACTIVATING SUPPORTS TOTAL PETROCHEMICALS RESEARCH FELUY (BE) 2009-01-29 WO disclosed
US-7005398-B2 Olefin polymerization catalyst, catalyst component for olefin polymerization, method of storing these, and process for producing olefin polymer SUNALLOMER LTD. (JP) 2006-02-28 US disclosed
US-20040054102-A1 Olefin polymerization catalyst, catalyst component for olefin polymerization, method of storing these, and process for producing olefin polymer SUNALLOMER LTD. (JP) 2004-03-18 US disclosed
EP-1359166-A1 OLEFIN POLYMERIZATION CATALYST, CATALYST COMPONENT FOR OLEFIN POLYMERIZATION, METHOD OF STORING THESE, AND PROCESS FOR PRODUCING OLEFIN POLYMER Sunallomer Ltd (JP) 2003-11-05 EP disclosed