Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HSPB1 | P04792 | 2/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.40 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.40 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8331117 | 0.90 | HSPB1 (0.44) | HSPB1PTGS2CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL27386744 | 0.86 | MAPT (0.46) | HSPB1CYP19A1CYP11B1CYP11B2MAPT | |
| SCHEMBL8444172 | 0.82 | NCOA1 (0.58) | HSPB1PTGS2FFAR4NCOA1NCOA3 | |
| SCHEMBL8332373 | 0.80 | ACHE (0.51) | HSPB1PTGS2FFAR4NCOA1NCOA3 | |
| SCHEMBL9812692 | 0.79 | ADRA2A (0.50) | HSPB1PTGS2CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL9087468 | 0.79 | HSPB1 (0.59) | HSPB1MAPTALDH1A1KDM4EMEN1 | |
| SCHEMBL27324556 | 0.79 | MEN1 (0.47) | HSPB1CYP19A1CYP11B1CYP11B2MAPT | |
| Water SCHEMBL11780560 | 0.78 | ADRA2A (0.49) | HSPB1PTGS2CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL9405534 | 0.78 | ADRA2A (0.47) | HSPB1PTGS2FFAR4NCOA1NCOA3 | |
| SCHEMBL8444830 | 0.77 | PTGS2 (0.47) | HSPB1PTGS2FFAR4KCNH2NCOA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5310737-A | Benzo-fused lactams that promote the release of growth hormone | MERCK & CO., INC. (US) | 1994-05-10 | — | — | US | disclosed |