Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL504447 | 0.72 | LMNA (0.36) | HTTRAB9AOPRK1CYP2D6CYP2C19 | |
| SCHEMBL8196334 | 0.72 | CYP2D6 (0.36) | SMN1; SMN2ALDH1A1HTTKDM4ERAB9A | |
| SCHEMBL10852706 | 0.70 | ALOX5 (0.40) | SMN1; SMN2ALDH1A1HTTKDM4ERAB9A | |
| SCHEMBL11177903 | 0.69 | SMN1; SMN2 (0.34) | SMN1; SMN2ALDH1A1HTTKDM4ERAB9A | |
| SCHEMBL11088915 | 0.66 | ALDH1A1 (0.43) | SMN1; SMN2ALDH1A1HTTKDM4ERAB9A | |
| SCHEMBL7959200 | 0.65 | ALDH1A1 (0.50) | SMN1; SMN2ALDH1A1HTTKDM4ERAB9A | |
| SCHEMBL7959203 | 0.65 | ALDH1A1 (0.50) | SMN1; SMN2ALDH1A1HTTKDM4ERAB9A | |
| SCHEMBL7131909 | 0.63 | IMPDH2 (0.40) | SMN1; SMN2ALDH1A1HTTKDM4ERAB9A | |
| SCHEMBL2827514 | 0.63 | GAA (0.41) | SMN1; SMN2ALDH1A1HTTKDM4ERAB9A | |
| SCHEMBL7131905 | 0.63 | IMPDH2 (0.40) | SMN1; SMN2ALDH1A1HTTKDM4ERAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5371086-A | Circulatory disorders side effect reduction | THE GREEN CROSS CORPORATION (JP) | 1994-12-06 | — | — | US | disclosed |
| EP-0609518-A1 | Optically active aminopyridine derivative and use thereof | THE GREEN CROSS CORPORATION (JP) | 1994-08-10 | — | — | EP | disclosed |
| US-5262415-A | FOR TREATING DISEASES OF THE CIRCULATORY SYSTEM | THE GREEN CROSS CORPORATION (JP) | 1993-11-16 | — | — | US | disclosed |
| EP-0503627-A1 | Aminopyridine compounds | THE GREEN CROSS CORPORATION (JP) | 1992-09-16 | — | — | EP | disclosed |