Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | SIRT2 | Q8IXJ6 | 6/20 | 0.51 |
| ▸ | SIRT1 | Q96EB6 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | PARP1 | P09874 | 1/20 | 0.49 |
| ▸ | CSF1R | P07333 | 1/20 | 0.48 |
| ▸ | MPO | P05164 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | CDC7 | O00311 | 1/20 | 0.45 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.45 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.45 |
| ▸ | PIM1 | P11309 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9409093 | 0.90 | LMNA (0.52) | LMNASIRT2SIRT1MEN1KMT2A | |
| SCHEMBL9409080 | 0.81 | BRAF (0.55) | SIRT2SIRT1KMT2APARP1TSHR | |
| SCHEMBL2391240 | 0.81 | MEN1 (0.50) | SIRT2MEN1KMT2ACSF1RPRKD3 | |
| SCHEMBL2723037 | 0.80 | SIRT2 (0.58) | SIRT2SIRT1HPGD | |
| SCHEMBL9409184 | 0.80 | SYK (0.57) | SIRT2SIRT1MEN1KMT2APARP1 | |
| SCHEMBL9409032 | 0.79 | SIRT2 (0.59) | SIRT2SIRT1 | |
| SCHEMBL9409098 | 0.76 | AKR1C3 (0.63) | LMNASIRT2SIRT1MEN1KMT2A | |
| SCHEMBL9409068 | 0.76 | SYK (0.52) | LMNASIRT2SIRT1MEN1KMT2A | |
| SCHEMBL9409040 | 0.76 | SIRT1 (0.57) | SIRT2SIRT1 | |
| SCHEMBL9496511 | 0.76 | LMNA (1.00) | LMNAMEN1KMT2ACSF1RNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0600832-A1 | Derivatives of diamino benzoic and diamino phthalic acid und their use as protein linase inhibitors | CIBA-GEIGY AG (CH) | 1994-06-08 | — | — | EP | claimed |
| EP-0600832-A1 | Derivatives of diamino benzoic and diamino phthalic acid und their use as protein linase inhibitors | CIBA-GEIGY AG (CH) | 1994-06-08 | — | — | EP | disclosed |