Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 7/20 | 0.47 |
| ▸ | BRAF | P15056 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.46 |
| ▸ | PAK4 | O96013 | 1/20 | 0.46 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | AKT1 | P31749 | 1/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.46 |
| ▸ | PLK1 | P53350 | 1/20 | 0.46 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.46 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.46 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.46 |
| ▸ | SIRT1 | Q96EB6 | 3/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9409080 | 0.90 | BRAF (0.55) | SIRT2BRAFCHEK1PAK4CSNK2A2 | |
| SCHEMBL9409034 | 0.86 | ALDH1A1 (0.56) | SIRT2MAPTALOX15MAPK1ALDH1A1 | |
| SCHEMBL9409200 | 0.86 | AKR1C3 (0.52) | SIRT2MAPTALOX15MAPK1SIRT1 | |
| SCHEMBL9409202 | 0.85 | MAPT (0.64) | SIRT2MAPTALOX15SIRT1PDE4B | |
| SCHEMBL9409093 | 0.85 | LMNA (0.52) | SIRT2MAPTALOX15SIRT1PDE4B | |
| SCHEMBL9409049 | 0.85 | AKR1C3 (0.58) | SIRT2MAPTSIRT1PDE4B | |
| SCHEMBL9409026 | 0.84 | SIRT2 (0.55) | SIRT2MAPTALOX15SIRT1PDE4B | |
| SCHEMBL9409168 | 0.84 | AKR1C3 (0.56) | SIRT2MAPTALOX15ALDH1A1 | |
| SCHEMBL9409059 | 0.83 | ALDH1A1 (0.58) | SIRT2MAPTMAPK1ALDH1A1 | |
| SCHEMBL9409066 | 0.82 | PDE4B (0.47) | SIRT2MAPTALOX15SIRT1PDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0600832-A1 | Derivatives of diamino benzoic and diamino phthalic acid und their use as protein linase inhibitors | CIBA-GEIGY AG (CH) | 1994-06-08 | — | — | EP | disclosed |