Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.64 |
| ▸ | SIRT2 | Q8IXJ6 | 11/20 | 0.58 |
| ▸ | SIRT1 | Q96EB6 | 4/20 | 0.49 |
| ▸ | BRD4 | O60885 | 1/20 | 0.49 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.49 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.49 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | CFTR | P13569 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5809618 | 0.92 | MAPT (0.74) | MAPTALOX15SIRT2AKR1C3AKR1C2 | |
| SCHEMBL2723037 | 0.88 | SIRT2 (0.58) | MAPTSIRT2SIRT1BRD4CXCR2 | |
| SCHEMBL9409210 | 0.87 | SIRT2 (0.58) | MAPTALOX15SIRT2AKR1C3AKR1C2 | |
| SCHEMBL9409094 | 0.86 | SIRT2 (0.54) | MAPTALOX15SIRT2AKR1C3AKR1C2 | |
| SCHEMBL9409168 | 0.86 | AKR1C3 (0.56) | MAPTALOX15SIRT2AKR1C3AKR1C2 | |
| SCHEMBL9409062 | 0.85 | SIRT2 (0.47) | MAPTALOX15SIRT2SIRT1CXCR2 | |
| SCHEMBL9409200 | 0.85 | AKR1C3 (0.52) | MAPTALOX15SIRT2SIRT1AKR1C3 | |
| SCHEMBL9409034 | 0.85 | ALDH1A1 (0.56) | MAPTALOX15SIRT2AKR1C3AKR1C2 | |
| SCHEMBL8529851 | 0.85 | MAPT (0.74) | MAPTALOX15SIRT2AKR1C3AKR1C2 | |
| SCHEMBL9409104 | 0.85 | SIRT2 (0.52) | MAPTALOX15SIRT2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0600832-A1 | Derivatives of diamino benzoic and diamino phthalic acid und their use as protein linase inhibitors | CIBA-GEIGY AG (CH) | 1994-06-08 | — | — | EP | claimed |
| EP-0600832-A1 | Derivatives of diamino benzoic and diamino phthalic acid und their use as protein linase inhibitors | CIBA-GEIGY AG (CH) | 1994-06-08 | — | — | EP | disclosed |