Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 5/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | IKBKB | O14920 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9409044 | 0.93 | MAPT (0.56) | SIRT2MAPTSMN1; SMN2LMNAHTT | |
| SCHEMBL9409094 | 0.85 | SIRT2 (0.54) | SIRT2MAPTSMN1; SMN2LMNAKMT2A | |
| SCHEMBL9409026 | 0.85 | SIRT2 (0.55) | SIRT2MAPTSMN1; SMN2LMNAHTT | |
| SCHEMBL9409104 | 0.84 | SIRT2 (0.52) | SIRT2MAPTSMN1; SMN2LMNAHTT | |
| SCHEMBL9409132 | 0.84 | AKR1C3 (0.55) | SIRT2MAPTLMNAKMT2AMEN1 | |
| SCHEMBL9409039 | 0.84 | SIRT2 (0.56) | SIRT2MAPTSMN1; SMN2LMNAKMT2A | |
| SCHEMBL9409202 | 0.84 | MAPT (0.64) | SIRT2MAPTALOX15ALDH1A1GAA | |
| SCHEMBL9409210 | 0.83 | SIRT2 (0.58) | SIRT2MAPTSMN1; SMN2ALOX15KDM4E | |
| SCHEMBL9409084 | 0.82 | SIRT2 (0.73) | SIRT2MAPTSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL9409105 | 0.81 | SIRT2 (0.49) | SIRT2MAPTKMT2AMEN1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0600832-A1 | Derivatives of diamino benzoic and diamino phthalic acid und their use as protein linase inhibitors | CIBA-GEIGY AG (CH) | 1994-06-08 | — | — | EP | disclosed |