Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Pyridazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH | Q9Y2I1 | 11/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.38 |
| ▸ | UBE2N | P61088 | 1/20 | 0.36 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL9412972 | 0.71 | NISCH (0.51) | NISCHACHE | |
| Bicarbonate SCHEMBL9375006 | 0.69 | NISCH (0.52) | NISCHACHE | |
| Hydrochloric Acid SCHEMBL6730399 | 0.63 | NISCH (0.62) | NISCHACHEUBE2NPAX8 | |
| SCHEMBL1526540 | 0.63 | NISCH (0.60) | NISCH | |
| SCHEMBL105024 | 0.62 | NISCH (1.00) | NISCH | |
| Pyridazine SCHEMBL7889331 | 0.62 | CA1 (0.39) | — | |
| Pyromellitic Acid SCHEMBL28372633 | 0.62 | NISCH (0.71) | NISCHACHEUBE2NPAX8 | |
| Pyromellitic Acid SCHEMBL216326 | 0.62 | NISCH (0.71) | NISCHACHEUBE2NPAX8 | |
| SCHEMBL11134114 | 0.62 | ACHE (0.62) | NISCHACHEUBE2NPAX8 | |
| SCHEMBL14496851 | 0.62 | NISCH (0.62) | NISCHADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0580042-A2 | Imidazolinyl-pyrrolo-pyridazines | BAYER AG (DE) | 1994-01-26 | — | — | EP | disclosed |