Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A known ✓ | P28223 | 7/20 | 0.46 |
| ▸ | HTR4 known ✓ | Q13639 | 6/20 | 0.46 |
| ▸ | KCNH2 known ✓ | Q12809 | 3/20 | 0.45 |
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 6/20 | 0.56 |
| ▸ | BCHE | P06276 | 3/20 | 0.47 |
| ▸ | DRD3 | P35462 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9411224 | 0.93 | ACHE (0.56) | ACHEBCHEHTR2AHTR4KCNH2 | |
| Fumaric Acid SCHEMBL9411426 | 0.92 | ACHE (0.50) | ACHEBCHEHTR2AMEN1KMT2A | |
| Fumaric Acid SCHEMBL9411430 | 0.92 | ACHE (0.50) | ACHEBCHEHTR2AMEN1KMT2A | |
| Fumaric Acid SCHEMBL9411508 | 0.86 | HTR2A (0.43) | ACHEBCHEHTR2AMEN1KMT2A | |
| Fumaric Acid SCHEMBL9411514 | 0.86 | HTR2A (0.43) | ACHEBCHEHTR2AMEN1KMT2A | |
| Fumaric Acid SCHEMBL9411620 | 0.84 | ACHE (0.48) | ACHEBCHEHTR2AKMT2ADRD3 | |
| SCHEMBL9411267 | 0.84 | ACHE (0.52) | ACHEHTR2AKCNH2 | |
| Maleic Acid SCHEMBL9411410 | 0.82 | ACHE (0.84) | ACHEBCHE | |
| Fumaric Acid SCHEMBL6989960 | 0.82 | ACHE (0.84) | ACHEBCHE | |
| Fumaric Acid SCHEMBL6989955 | 0.82 | ACHE (0.84) | ACHEBCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0602242-A1 | BENZISOXAZOLE COMPOUND AND USE THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1994-06-22 | — | — | EP | disclosed |