Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | CHKA | P35790 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12992270 | 0.92 | SIGMAR1 (0.45) | SIGMAR1MAPTHRH3APP | |
| SCHEMBL9414462 | 0.92 | SIGMAR1 (0.45) | SIGMAR1MAPTHRH3APP | |
| SCHEMBL8308762 | 0.86 | IDO1 (0.44) | SIGMAR1HRH3APP | |
| SCHEMBL8311656 | 0.82 | HSD17B10 (0.39) | SIGMAR1HRH3RAB9AALDH1A1APP | |
| SCHEMBL7833142 | 0.82 | KMT2A (0.55) | RAB9AALDH1A1APP | |
| SCHEMBL18469979 | 0.80 | MC4R (0.46) | SIGMAR1HRH3CHRM1 | |
| SCHEMBL8307284 | 0.79 | TDP1 (0.50) | SIGMAR1ALDH1A1APP | |
| SCHEMBL24220107 | 0.79 | SMN1; SMN2 (0.52) | MAPTRAB9AALDH1A1GAAL3MBTL1 | |
| SCHEMBL3518321 | 0.79 | CHRM1 (0.46) | SIGMAR1HRH3APPCHRM5CHRM1 | |
| SCHEMBL3520050 | 0.79 | CHRM1 (0.46) | SIGMAR1HRH3APPCHRM5CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0597821-A1 | 2-(Heterocyclylthio)carbapenem derivatives their preparation and their use as antibiotics | Sankyo Company Limited (JP) | 1994-05-18 | — | — | EP | disclosed |
| US-5242914-A | 2-(heterocyclylthio) carbapenem derivatives, their preparation and their use as antibiotics | SANKYO COMPANY, LIMITED (JP) | 1993-09-07 | — | — | US | disclosed |
| US-5104867-A | 2-(HETEROCYCLYLTHIO)CARBAPENEM DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ANTIBIOTICS | SANKYO COMPANY, LIMITED (JP) | 1992-04-14 | — | — | US | disclosed |
| EP-0337637-A1 | 2-(Heterocyclylthio)carbapenem derivatives their preparation and their use as antibiotics | Sankyo Company Limited (JP) | 1989-10-18 | — | — | EP | disclosed |