Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.46 |
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.46 |
| ▸ | ADRA2B known ✓ | P18089 | 1/20 | 0.46 |
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.46 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.46 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 2/20 | 0.47 |
| ▸ | DRD1 | P21728 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6292185 | 0.99 | ALDH1A1 (0.48) | ALDH1A1ALDH3A1DRD2DRD1KMT2A | |
| SCHEMBL6291580 | 0.84 | SIGMAR1 (0.44) | DRD2CYP1A2CYP3A4HTR1ADRD3 | |
| SCHEMBL6292075 | 0.83 | CYP1A2 (0.43) | ALDH3A1DRD2DRD1CYP1A2CYP3A4 | |
| SCHEMBL3750412 | 0.78 | CYP1A2 (0.44) | ALDH1A1CYP1A2CYP3A4GAAHSD17B10 | |
| SCHEMBL9414681 | 0.76 | DRD2 (0.51) | DRD2CYP1A2CYP3A4HTR1ADRD3 | |
| SCHEMBL9414685 | 0.76 | CYP1A2 (0.52) | DRD2CYP1A2CYP3A4HTR1A | |
| SCHEMBL9414742 | 0.74 | HTR2C (0.51) | DRD2CYP1A2CYP3A4HTR1A | |
| SCHEMBL6292082 | 0.74 | SIGMAR1 (0.47) | HTR1ASMN1; SMN2 | |
| SCHEMBL8203911 | 0.73 | DRD2 (0.75) | ALDH1A1ALDH3A1DRD2DRD1KMT2A | |
| SCHEMBL9414716 | 0.73 | CYP3A4 (0.72) | ALDH1A1DRD2KMT2AMEN1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0594877-A1 | Imidazo(1,2-c)quinazoline derivates as antihyper tensives and anti dysurics | NATIONAL SCIENCE COUNCIL (TW) | 1994-05-04 | — | — | EP | disclosed |
| US-5158953-A | 2-substituted methyl-2,3-dihydroimidazo[1,2-c]quinazolin-5(6H)-ones (thiones), the preparation and use thereof | NATIONAL SCIENCE COUNCIL (TW) | 1992-10-27 | — | — | US | disclosed |