Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.72 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.72 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.72 |
| ▸ | HTR2C | P28335 | 3/20 | 0.52 |
| ▸ | DRD2 | P14416 | 2/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.51 |
| ▸ | HTR1A | P08908 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.48 |
| ▸ | HTR7 | P34969 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9414685 | 0.86 | CYP1A2 (0.52) | CYP3A4CYP1A2CYP2C9DRD2HTR2A | |
| SCHEMBL9414681 | 0.83 | DRD2 (0.51) | CYP3A4CYP1A2CYP2C9DRD2HTR1A | |
| SCHEMBL3750412 | 0.80 | CYP1A2 (0.44) | CYP3A4CYP1A2CYP2C9ALDH1A1HSD17B10 | |
| SCHEMBL9414742 | 0.80 | HTR2C (0.51) | CYP3A4CYP1A2CYP2C9HTR2CDRD2 | |
| SCHEMBL9414729 | 0.80 | CYP1A2 (0.53) | CYP3A4CYP1A2CYP2C9DRD2HTR2A | |
| SCHEMBL8326424 | 0.79 | DRD2 (0.63) | CYP3A4CYP1A2CYP2C9HTR2CDRD2 | |
| SCHEMBL6292075 | 0.77 | CYP1A2 (0.43) | CYP3A4CYP1A2CYP2C9HTR2CDRD2 | |
| SCHEMBL6292082 | 0.74 | SIGMAR1 (0.47) | HTR1A | |
| SCHEMBL6292185 | 0.74 | ALDH1A1 (0.48) | CYP3A4CYP1A2DRD2HTR1AALDH1A1 | |
| Bromide SCHEMBL9414720 | 0.73 | ALDH1A1 (0.48) | CYP3A4CYP1A2DRD2HTR1AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0594877-A1 | Imidazo(1,2-c)quinazoline derivates as antihyper tensives and anti dysurics | NATIONAL SCIENCE COUNCIL (TW) | 1994-05-04 | — | — | EP | disclosed |
| US-5158953-A | 2-substituted methyl-2,3-dihydroimidazo[1,2-c]quinazolin-5(6H)-ones (thiones), the preparation and use thereof | NATIONAL SCIENCE COUNCIL (TW) | 1992-10-27 | — | — | US | disclosed |