Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 12/20 | 0.43 |
| ▸ | QRFPR | Q96P65 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9417278 | 0.91 | CTSL (0.44) | REN | |
| SCHEMBL7302163 | 0.89 | REN (0.48) | REN | |
| SCHEMBL9417286 | 0.89 | QRFPR (0.46) | RENQRFPR | |
| SCHEMBL7280728 | 0.88 | REN (0.51) | REN | |
| SCHEMBL7280722 | 0.88 | REN (0.51) | REN | |
| SCHEMBL9442804 | 0.86 | REN (0.37) | RENQRFPR | |
| SCHEMBL7284371 | 0.82 | REN (0.52) | REN | |
| SCHEMBL7284363 | 0.82 | REN (0.52) | REN | |
| SCHEMBL9417281 | 0.81 | CTSL (0.46) | — | |
| SCHEMBL10408622 | 0.80 | MMP2 (0.44) | REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0229667-B1 | Peptidylaminodiols | ABBOTT LAB (US) | 1994-07-13 | — | — | EP | disclosed |
| US-5214129-A | Amidation of a protected amino acid by an di-O-protected dihydroxy-containing amine and coupling with a carboxylic acid; deprotecting; renin inhibitors; hypotensive agents | ABBOTT LABORATORIES (US) | 1993-05-25 | — | — | US | disclosed |
| US-5091575-A | Renin inhibitor | ABBOTT LABORATORIES (US) | 1992-02-25 | — | — | US | disclosed |
| US-5032577-A | Hypotensive | ABBOTT LABORATORIES (US) | 1991-07-16 | — | — | US | disclosed |
| US-4845079-A | HYPOTENSIVE, RENIN INHIBITION | ABBOTT LABORATORIES | 1989-07-04 | — | — | US | disclosed |