Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 7/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.49 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CCKBR | P32239 | 1/20 | 0.41 |
| ▸ | YAP1 | P46937 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7284363 | 1.00 | REN (0.52) | RENMAPTMAPK1NPSR1KMT2A | |
| SCHEMBL7280728 | 0.87 | REN (0.51) | REN | |
| SCHEMBL7280722 | 0.87 | REN (0.51) | REN | |
| SCHEMBL7302163 | 0.83 | REN (0.48) | RENNPSR1KMT2AMEN1 | |
| SCHEMBL9417301 | 0.82 | REN (0.43) | REN | |
| SCHEMBL9417278 | 0.80 | CTSL (0.44) | RENMAPT | |
| SCHEMBL7381400 | 0.79 | KMT2A (0.51) | RENMAPTMAPK1NPSR1KMT2A | |
| SCHEMBL7307138 | 0.79 | KMT2A (0.51) | RENMAPTMAPK1NPSR1KMT2A | |
| SCHEMBL9551311 | 0.78 | REN (0.64) | RENCCKBR | |
| SCHEMBL10408622 | 0.76 | MMP2 (0.44) | REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992007845-A1 | DERIVATIVES OF AMINO ACIDS AS INHIBITORS OF RENIN, METHODS FOR THEIR PREPARATION, MEDICAMENTS CONTAINING THEM AND THEIR USE | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-05-14 | — | — | WO | disclosed |
| EP-0483403-A1 | Derivatives of amino acids as inhibitors of renin, methods for their preparation, medicaments containing them and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-05-06 | — | — | EP | disclosed |