Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.45 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 7/20 | 0.41 |
| ▸ | DRD2 | P14416 | 6/20 | 0.41 |
| ▸ | DRD3 | P35462 | 5/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.41 |
| ▸ | HTR1A | P08908 | 3/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.41 |
| ▸ | HTR2A | P28223 | 3/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.41 |
| ▸ | HRH1 | P35367 | 3/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.41 |
| ▸ | DRD1 | P21728 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9419616 | 0.73 | HTR1A (0.62) | SIGMAR1CHRM1DRD2DRD3CHRM2 | |
| SCHEMBL13305256 | 0.73 | KDM1A (0.61) | SIGMAR1SMPD1CHRM1DRD2DRD3 | |
| SCHEMBL6102599 | 0.72 | CACNA1B (0.51) | SIGMAR1SMPD1CHRM1DRD2DRD3 | |
| SCHEMBL5051922 | 0.71 | CA1 (0.39) | SIGMAR1KMT2AMAPK1CYP1A2CA1 | |
| SCHEMBL6045244 | 0.70 | PIM1 (0.41) | SIGMAR1SMPD1MEN1KMT2AKDM1A | |
| SCHEMBL6969785 | 0.70 | CACNA1B (0.50) | SIGMAR1SMPD1CHRM1DRD2DRD3 | |
| SCHEMBL6968853 | 0.70 | DRD2 (0.54) | SIGMAR1CHRM1DRD2DRD3CHRM2 | |
| SCHEMBL2016258 | 0.70 | LTA4H (0.57) | SIGMAR1MEN1KMT2ACYP3A4CYP1A2 | |
| SCHEMBL2019556 | 0.70 | LTA4H (0.57) | SIGMAR1MEN1KMT2ACYP3A4CYP1A2 | |
| SCHEMBL2016261 | 0.70 | LTA4H (0.57) | SIGMAR1MEN1KMT2ACYP3A4CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5371081-A | Useful in potentiating the cytotoxic effect of chemotherapeutic agents | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 1994-12-06 | — | — | US | claimed |
| WO-1993003729-A1 | N-SUBSTITUTED PHENOXAZINES FOR TREATING MULTIDRUG RESISTANT CANCER CELLS | RESEARCH CORPORATION TECHNOLOGIES, INC. (US) | 1993-03-04 | — | — | WO | claimed |
| US-5371081-A | Useful in potentiating the cytotoxic effect of chemotherapeutic agents | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 1994-12-06 | — | — | US | disclosed |
| WO-1993003729-A1 | N-SUBSTITUTED PHENOXAZINES FOR TREATING MULTIDRUG RESISTANT CANCER CELLS | RESEARCH CORPORATION TECHNOLOGIES, INC. (US) | 1993-03-04 | — | — | WO | disclosed |