SCHEMBL9419902

SCHEMBL9419902

O=C(NN=C(Cc1ccc(Cl)cc1)c1ccc(Cl)cc1)Nc1ccc(C(F)(F)F)cc1

nearest known ligand 0.57

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CNR1 P21554 2/20 0.57
EPHX2 P34913 3/20 0.51
RHOC P08134 1/20 0.49
RHOA P61586 1/20 0.49
IDH1 O75874 1/20 0.47
GRIK1 P39086 1/20 0.47
STAT3 P40763 1/20 0.47
CNR2 P34972 1/20 0.46
MEN1 O00255 2/20 0.46
KMT2A Q03164 2/20 0.46
MAPT P10636 1/20 0.46
HTT P42858 1/20 0.46
RAB9A P51151 1/20 0.46
HIF1A Q16665 1/20 0.46
EPAS1 Q99814 1/20 0.46
MTOR P42345 1/20 0.45
ALDH1A1 P00352 1/20 0.45
POLB P06746 1/20 0.45
HPGD P15428 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9018902 0.89 EPHX2 (0.52) EPHX2MEN1KMT2AMAPTHTT
SCHEMBL6903409 0.85 CNR2 (0.50) CNR1RHOCRHOACNR2MAPT
SCHEMBL9508161 0.84 KDM4E (0.52) CNR1EPHX2GRIK1MEN1KMT2A
SCHEMBL9018884 0.83 TP53 (0.58) CNR1MEN1KMT2AMAPTRAB9A
SCHEMBL9018855 0.82 RAB9A (0.54) CNR1GRIK1MEN1KMT2ARAB9A
SCHEMBL13964164 0.82 MTOR (0.50) EPHX2IDH1MEN1KMT2AMAPT
SCHEMBL9018847 0.81 SAE1 (0.49) EPHX2IDH1MEN1KMT2AMAPT
SCHEMBL6341024 0.80 SMN1; SMN2 (0.47) EPHX2RHOCRHOACNR2MEN1
SCHEMBL6341025 0.80 SMN1; SMN2 (0.47) EPHX2RHOCRHOACNR2MEN1
SCHEMBL4922162 0.79 EPHX2 (0.81) CNR1EPHX2RHOCRHOAIDH1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5288727-A Hydrazone compounds, processes for their production, intermediates useful for their production and pesticidal compositions containing them ISHIHARA SANGYO KAISHA LTD. (JP) 1994-02-22 US disclosed
EP-0500111-A2 Hydrazone compounds, processes for their production, intermediates useful for their production and pesticidal compositions containing them ISHIHARA SANGYO KAISHA, LTD. (JP) 1992-08-26 EP disclosed