Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9421081 | 1.00 | LMNA (0.42) | LMNASMN1; SMN2HTTKDM4EALDH1A1 | |
| SCHEMBL9421069 | 0.85 | MEN1 (0.33) | LMNASMN1; SMN2HTTKDM4EALDH1A1 | |
| SCHEMBL9421076 | 0.85 | MEN1 (0.33) | LMNASMN1; SMN2HTTKDM4EALDH1A1 | |
| SCHEMBL9421078 | 0.85 | MEN1 (0.33) | LMNASMN1; SMN2HTTKDM4EALDH1A1 | |
| SCHEMBL10532639 | 0.73 | RXRA (0.40) | LMNAHTTALDH1A1MAPTGAA | |
| SCHEMBL9421054 | 0.73 | RXRA (0.40) | LMNAHTTALDH1A1MAPTGAA | |
| SCHEMBL10584331 | 0.73 | RXRA (0.40) | LMNAHTTALDH1A1MAPTGAA | |
| SCHEMBL9421063 | 0.73 | RXRA (0.40) | LMNAHTTALDH1A1MAPTGAA | |
| SCHEMBL9421102 | 0.71 | ALDH1A1 (0.50) | LMNASMN1; SMN2HTTKDM4EALDH1A1 | |
| SCHEMBL9579906 | 0.71 | ALDH1A1 (0.50) | LMNASMN1; SMN2HTTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5332857-A | 3,5-dihydroxy-6,8-nonadienoic acids and derivatives as hypocholesterolemic agents | PFIZER INC. (US) | 1994-07-26 | — | — | US | disclosed |
| US-5151545-A | 3,5-DIHYDROXY-6,8-NONADIENOIC ACIDS AND DERIVATIVES AS HYPOCHOLESTEROLEMIC AGENTS | PFIZER INC. (US) | 1992-09-29 | — | — | US | disclosed |
| EP-0312269-A2 | 3,5-Dihydroxy-6,8-nonadienoic acids and derivatives as hypocholesterolemic agents | PFIZER INC. (US) | 1989-04-19 | — | — | EP | disclosed |