Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | METAP1 | P53582 | 6/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1122615 | 0.75 | GAA (0.35) | POLBGAA | |
| SCHEMBL3350738 | 0.75 | GAA (0.35) | POLBGAA | |
| SCHEMBL1123030 | 0.75 | GAA (0.35) | POLBGAA | |
| SCHEMBL8792481 | 0.68 | KDM4E (0.38) | POLBGAA | |
| SCHEMBL7818373 | 0.65 | HTR7 (0.44) | — | |
| SCHEMBL9653835 | 0.61 | POLB (0.31) | POLBGAA | |
| SCHEMBL2307894 | 0.60 | GAA (0.55) | POLBGAA | |
| SCHEMBL9422893 | 0.59 | GAA (0.33) | POLBGAA | |
| SCHEMBL9651685 | 0.58 | CA2 (0.31) | — | |
| Hydrochloric Acid SCHEMBL7290256 | 0.58 | METAP1 (0.46) | METAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5334591-A | Useful in the treatment of ocular hypertension and glaucoma | MERCK & CO., INC. (US) | 1994-08-02 | — | — | US | disclosed |
| EP-0543497-A1 | Tricyclic thienothiopyrans as antiglancoma agents | MERCK & CO. INC. (US) | 1993-05-26 | — | — | EP | disclosed |
| US-5175284-A | Glaucoma | MERCK & CO., INC. (US) | 1992-12-29 | — | — | US | disclosed |