Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 5/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 5/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9423924 | 0.78 | SCN9A (0.48) | HPGDALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL9424123 | 0.77 | ALDH1A1 (0.60) | HPGDALDH1A1KDM4EHTTMAPT | |
| SCHEMBL4807592 | 0.77 | ALDH1A1 (0.67) | ALDH1A1KDM4EPOLBHTTMAPT | |
| SCHEMBL9424481 | 0.74 | ALDH1A1 (0.47) | HPGDALDH1A1KDM4EPOLBMAPT | |
| SCHEMBL17979907 | 0.72 | ALDH1A1 (0.58) | HPGDALDH1A1KDM4EPOLBHTT | |
| SCHEMBL3723928 | 0.72 | ALDH1A1 (0.54) | ALDH1A1KDM4EPOLBHTTMAPT | |
| SCHEMBL9423881 | 0.72 | LMNA (0.50) | ALDH1A1KDM4EPOLBMAPTMEN1 | |
| SCHEMBL29838620 | 0.70 | ALDH1A1 (0.68) | ALDH1A1POLBHTTMAPTMEN1 | |
| SCHEMBL5447861 | 0.70 | ALDH1A1 (0.68) | ALDH1A1POLBHTTMAPTMEN1 | |
| SCHEMBL29998429 | 0.69 | ALDH1A1 (0.66) | HPGDALDH1A1KDM4EPOLBHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1037346-C | Therapeutic agents | BOOTS CO LTD (GB) | 1998-02-11 | — | — | CN | disclosed |
| US-5373008-A | Phenylamidine and phenylguanidine derivatives and their use as anti-diabetic agents | THE BOOTS COMPANT PLC. (GB) | 1994-12-13 | — | — | US | disclosed |
| US-5223498-A | Hypoglycemic agents | THE BOOTS COMPANY PLC (GB) | 1993-06-29 | — | — | US | disclosed |
| EP-0385038-B1 | ORTHO-SUBSTITUTED PHENYL AMIDINE AND PHENYL GUANIDINE DERIVATIVES AND ANTIDIABETIC OR HYPOGLYCAEMIC AGENTS CONTAINING THEM | The Boots Company PLC (GB) | 1993-06-02 | — | — | EP | disclosed |
| CN-1057648-A | Therapeutical agent | BOOTS CO PLC (GB) | 1992-01-08 | — | — | CN | disclosed |
| EP-0385038-A1 | Ortho-substituted phenyl amidine and phenyl guanidine derivatives and antidiabetic or hypoglycaemic agents containing them | The Boots Company PLC (GB) | 1990-09-05 | — | — | EP | disclosed |