Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | PRKDC | P78527 | 2/20 | 0.47 |
| ▸ | CNR2 | P34972 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | CRHBP | P24387 | 1/20 | 0.47 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.47 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3723928 | 0.87 | ALDH1A1 (0.54) | ALDH1A1POLBLMNAPRKDCCNR2 | |
| SCHEMBL15093718 | 0.82 | ALDH1A1 (0.54) | ALDH1A1POLBLMNAPRKDCCNR2 | |
| SCHEMBL17979907 | 0.80 | ALDH1A1 (0.58) | ALDH1A1POLBMAPTHTTKDM4E | |
| SCHEMBL9424159 | 0.80 | ALDH1A1 (0.48) | ALDH1A1POLBLMNAPRKDCCNR2 | |
| SCHEMBL3723155 | 0.80 | CYP1A2 (0.54) | ALDH1A1POLBLMNAMAPTHTT | |
| SCHEMBL15462283 | 0.79 | ALDH1A1 (0.61) | ALDH1A1POLBLMNAMEN1MAPT | |
| SCHEMBL9424481 | 0.79 | ALDH1A1 (0.47) | ALDH1A1POLBLMNAPRKDCCNR2 | |
| SCHEMBL18027642 | 0.78 | CRHR1 (0.49) | ALDH1A1POLBLMNAMEN1MAPT | |
| SCHEMBL21893900 | 0.78 | ADRB1 (0.62) | ALDH1A1POLBLMNAPRKDCCNR2 | |
| SCHEMBL11503875 | 0.77 | ALDH1A1 (0.45) | ALDH1A1POLBLMNAPRKDCCNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022078306-A1 | LARGE STERIC HINDERANCE PALLADIUM-NITROGEN-HETEROCYCLIC CARBENE COMPLEX, PREPARATION METHOD FOR SAME, APPLICATIONS OF SAME, AND SYNTHESIS METHOD FOR SONIDEGIB BASED ON SAME | 中山大学 | 2022-04-21 | — | — | WO | disclosed |
| US-9340519-B2 | Paracyclophane-based ligands, their preparation and use in catalysis | JOHNSON MATTHEY PLC (GB) | 2016-05-17 | — | — | US | disclosed |
| US-9340519-B2 | Paracyclophane-based ligands, their preparation and use in catalysis | JOHNSON MATTHEY PLC (GB) | 2016-05-17 | — | — | US | disclosed |
| EP-2183259-B1 | PARACYCLOPHANE-BASED LIGANDS, THEIR PREPARATION AND USE IN CATALYSIS | JOHNSON MATTHEY PLC (GB) | 2015-10-21 | — | — | EP | disclosed |
| US-8969624-B2 | Cyclopentadienyl, indenyl or fluorenyl substituted phosphine compounds and their use in catalytic reactions | EVONIK DEGUSSA GMBH (DE) | 2015-03-03 | — | — | US | disclosed |
| US-8969624-B2 | Cyclopentadienyl, indenyl or fluorenyl substituted phosphine compounds and their use in catalytic reactions | EVONIK DEGUSSA GMBH (DE) | 2015-03-03 | — | — | US | disclosed |
| EP-2057174-B1 | NEW CYCLOPENTADIENYL, INDENYL OR FLUORENYL SUBSTITUTED PHOSPHINE COMPOUNDS AND THEIR USE IN CATALYTIC REACTIONS | EVONIK DEGUSSA GMBH (DE) | 2014-12-17 | — | — | EP | disclosed |
| US-20140330012-A1 | PARACYCLOPHANE-BASED LIGANDS, THEIR PREPARATION AND USE IN CATALYSIS | JOHNSON MATTHEY PUBLIC LIMITED COMPANY (GB) | 2014-11-06 | — | — | US | disclosed |
| US-20140330012-A1 | PARACYCLOPHANE-BASED LIGANDS, THEIR PREPARATION AND USE IN CATALYSIS | JOHNSON MATTHEY PUBLIC LIMITED COMPANY (GB) | 2014-11-06 | — | — | US | disclosed |
| US-8822680-B2 | Paracyclophane-based ligands, their preparation and use in catalysis | JOHNSON MATTHEY PLC (GB) | 2014-09-02 | — | — | US | disclosed |
| US-7442800-B2 | Nucleophilic heterocyclic carbene derivatives of Pd(acac)2 for cross-coupling reactions | PROMERUS LLC (US) | 2008-10-28 | — | — | US | disclosed |
| EP-1894938-A1 | New cyclopentadienyl, indenyl or fluorenyl substituted phosphine compounds and their use in catalytic reactions | Evonik Degussa GmbH (DE) | 2008-03-05 | — | — | EP | disclosed |
| EP-1885669-A1 | NUCLEOPHILIC HETEROCYCLIC CARBENE DERIVATIVES OF PD(ACAC)2 FOR CROSS-COUPLING REACTIONS | Promerus LLC (US) | 2008-02-13 | — | — | EP | disclosed |
| EP-1354887-B1 | Ligands for metals and improved metal-catalyzed processes based thereon | MASSACHUSETTS INST TECHNOLOGY (US) | 2007-04-25 | — | — | EP | disclosed |
| US-20060287544-A1 | Nucleophilic heterocyclic carbene derivatives of Pd(acac)2 for cross-coupling reactions | PROMERUS LLC (US) | 2006-12-21 | — | — | US | disclosed |
| WO-2006128097-A1 | NUCLEOPHILIC HETEROCYCLIC CARBENE DERIVATIVES OF PD(ACAC)2 FOR CROSS-COUPLING REACTIONS | PROMERUS LLC (US) | 2006-11-30 | — | — | WO | disclosed |
| EP-1097158-B1 | LIGANDS FOR METALS AND METAL-CATALYZED PROCESSES | MASSACHUSETTS INST TECHNOLOGY (US) | 2006-01-25 | — | — | EP | disclosed |
| EP-1354887-A1 | Ligands for metals and improved metal-catalyzed processes based thereon | Massachusetts Insitute of Technology (US) | 2003-10-22 | — | — | EP | disclosed |
| EP-1097158-A2 | LIGANDS FOR METALS AND METAL-CATALYZED PROCESSES | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2001-05-09 | — | — | EP | disclosed |
| WO-2000002887-A2 | LIGANDS FOR METALS AND METAL-CATALYZED PROCESSES | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2000-01-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060287544-A1 | Nucleophilic heterocyclic carbene derivatives of Pd(acac)2 for cross-coupling reactions | NDC1, DDC, PDCD1LG2 | ALDH1A1 893/4885POLB 687/4885LMNA 4016/4885 |
| US-20140330012-A1 | PARACYCLOPHANE-BASED LIGANDS, THEIR PREPARATION AND USE IN CATALYSIS | CYCS, HCCS, CYC1 | ALDH1A1 2283/4885POLB 541/4885LMNA 1031/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.