Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.43 |
| ▸ | PRKDC | P78527 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9059303 | 0.86 | SCN9A (0.48) | SCN9AHPGDKMT2AMEN1AKR1C3 | |
| SCHEMBL9423957 | 0.86 | L3MBTL1 (0.48) | KMT2AMEN1ALDH1A1LMNAMAPT | |
| SCHEMBL9059359 | 0.85 | HPGD (0.48) | SCN9AHPGDKMT2AMEN1AKR1C3 | |
| SCHEMBL20119967 | 0.79 | PRKDC (0.47) | SCN9AHPGDKMT2AMEN1AKR1C3 | |
| Iodide SCHEMBL9424394 | 0.78 | SCN9A (0.47) | SCN9AHPGDKMT2AMEN1AKR1C3 | |
| SCHEMBL9059639 | 0.78 | SCN9A (0.47) | SCN9AHPGDKMT2AMEN1AKR1C3 | |
| SCHEMBL9059454 | 0.78 | ALDH1A1 (0.49) | SCN9AKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL9423923 | 0.78 | HPGD (0.52) | HPGDKMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL9424123 | 0.77 | ALDH1A1 (0.60) | HPGDKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL9059428 | 0.76 | SCN9A (0.48) | SCN9AHPGDKMT2AMEN1AKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1037346-C | Therapeutic agents | BOOTS CO LTD (GB) | 1998-02-11 | — | — | CN | disclosed |
| US-5373008-A | Phenylamidine and phenylguanidine derivatives and their use as anti-diabetic agents | THE BOOTS COMPANT PLC. (GB) | 1994-12-13 | — | — | US | disclosed |
| US-5223498-A | Hypoglycemic agents | THE BOOTS COMPANY PLC (GB) | 1993-06-29 | — | — | US | disclosed |
| EP-0385038-B1 | ORTHO-SUBSTITUTED PHENYL AMIDINE AND PHENYL GUANIDINE DERIVATIVES AND ANTIDIABETIC OR HYPOGLYCAEMIC AGENTS CONTAINING THEM | The Boots Company PLC (GB) | 1993-06-02 | — | — | EP | disclosed |
| CN-1057648-A | Therapeutical agent | BOOTS CO PLC (GB) | 1992-01-08 | — | — | CN | disclosed |
| EP-0385038-A1 | Ortho-substituted phenyl amidine and phenyl guanidine derivatives and antidiabetic or hypoglycaemic agents containing them | The Boots Company PLC (GB) | 1990-09-05 | — | — | EP | disclosed |