Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FBP1 | P09467 | 8/20 | 0.53 |
| ▸ | IDH1 | O75874 | 5/20 | 0.48 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.46 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.46 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.45 |
| ▸ | CTSB | P07858 | 1/20 | 0.45 |
| ▸ | ELANE | P08246 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9424316 | 0.87 | FBP1 (0.52) | FBP1MEN1KMT2ALMNAMAPT | |
| SCHEMBL9424273 | 0.84 | IDH1 (0.49) | IDH1KCNJ6KCNJ5KCNJ3ALDH1A1 | |
| SCHEMBL9424464 | 0.80 | KMT2A (0.47) | FBP1IDH1MEN1KMT2AKLKB1 | |
| SCHEMBL9424478 | 0.78 | KMT2A (0.48) | FBP1IDH1MEN1KMT2AKLKB1 | |
| SCHEMBL9424731 | 0.76 | ALDH1A1 (0.51) | IDH1MEN1KMT2AMAPTHTT | |
| SCHEMBL9424704 | 0.75 | ALDH1A1 (0.44) | FBP1IDH1MEN1KMT2AKLKB1 | |
| SCHEMBL9424351 | 0.74 | FBP1 (0.49) | FBP1IDH1MEN1KMT2ALMNA | |
| SCHEMBL9424721 | 0.73 | MAPT (0.58) | FBP1MEN1KMT2ALMNAMAPT | |
| SCHEMBL8762900 | 0.73 | CA12 (0.57) | FBP1IDH1KCNJ6KCNJ5KCNJ3 | |
| SCHEMBL9424517 | 0.73 | KMT2A (0.47) | FBP1MEN1KMT2AKLKB1CTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5302724-A | Thiophenesulfonylureas; anticarcinogenic agents | ELI LILLY AND COMPANY (US) | 1994-04-12 | — | — | US | disclosed |
| CN-1058401-A | Anti-tumor compositions and methods of treatment | LILLY CO ELI (US) | 1992-02-05 | — | — | CN | disclosed |
| EP-0467613-A1 | Antitumor compositions and methods of treatment | ELI LILLY AND COMPANY (US) | 1992-01-22 | — | — | EP | disclosed |