Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 2/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 3/20 | 0.45 |
| ▸ | CA9 | Q16790 | 2/20 | 0.45 |
| ▸ | CA4 | P22748 | 1/20 | 0.45 |
| ▸ | CA5A | P35218 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 6/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9424554 | 0.99 | EPHX1 (0.49) | EPHX1EPHX2CYP3A4CA2CA9 | |
| SCHEMBL9424703 | 0.98 | EPHX1 (0.48) | EPHX1EPHX2CYP3A4CA2CA9 | |
| SCHEMBL9424464 | 0.87 | KMT2A (0.47) | CYP3A4CA2CA9MEN1KMT2A | |
| SCHEMBL9424478 | 0.85 | KMT2A (0.48) | CYP3A4CA2CA9MEN1KMT2A | |
| SCHEMBL9424859 | 0.84 | EPHX1 (0.51) | EPHX1EPHX2CA2CA9CA4 | |
| SCHEMBL9424579 | 0.83 | EPHX1 (0.53) | EPHX1EPHX2CA2CA9CA4 | |
| SCHEMBL9424863 | 0.82 | MAPT (0.53) | EPHX1EPHX2CA2CA9CA4 | |
| SCHEMBL9424316 | 0.81 | FBP1 (0.52) | EPHX1EPHX2CYP3A4CA2CA9 | |
| SCHEMBL9424704 | 0.78 | ALDH1A1 (0.44) | CYP3A4CA2CA9MEN1KMT2A | |
| SCHEMBL9424688 | 0.77 | EPHX1 (0.51) | EPHX1EPHX2CA2CA9CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5302724-A | Thiophenesulfonylureas; anticarcinogenic agents | ELI LILLY AND COMPANY (US) | 1994-04-12 | — | — | US | disclosed |
| EP-0467613-A1 | Antitumor compositions and methods of treatment | ELI LILLY AND COMPANY (US) | 1992-01-22 | — | — | EP | disclosed |