Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.48 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CDK8 | P49336 | 1/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9425827 | 0.81 | CDK8 (0.39) | TRPM8KMT2ARAB9ACDK8CLK4 | |
| SCHEMBL9426010 | 0.81 | CDK8 (0.39) | TRPM8KMT2ARAB9ACDK8CLK4 | |
| SCHEMBL9425793 | 0.81 | HPGD (0.58) | TRPM8HPGDTRPV1 | |
| SCHEMBL9425976 | 0.79 | TRPM8 (0.62) | TRPM8MEN1KMT2AHPGDRAB9A | |
| SCHEMBL8122254 | 0.79 | SIGMAR1 (0.45) | PTGDR2MEN1KMT2AHPGDRAB9A | |
| SCHEMBL9346628 | 0.78 | IAPP (0.62) | MEN1KMT2AHPGDRAB9ATP53 | |
| SCHEMBL9426557 | 0.78 | TRPM8 (0.57) | TRPM8HPGDTRPV1 | |
| SCHEMBL9425817 | 0.77 | TRPM8 (0.41) | TRPM8MEN1KMT2ARAB9AALDH1A1 | |
| SCHEMBL8349898 | 0.76 | TRPM8 (0.62) | TRPM8KMT2AHPGDRAB9AALDH1A1 | |
| SCHEMBL18414428 | 0.76 | TRPV1 (0.52) | HPGDRAB9ATP53MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5338745-A | Alzheimer's disease | MITSUI TOATSU CHEMICALS, INCORPORATION (JP) | 1994-08-16 | — | — | US | disclosed |
| EP-0495998-A1 | DIHYDROCAFFEIC ACID AMIDE DERIVATIVE AND APPLICATION THEREOF AS MEDICINE | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1992-07-29 | — | — | EP | disclosed |