Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 3/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.39 |
| ▸ | EBP | Q15125 | 3/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.38 |
| ▸ | DRD3 | P35462 | 2/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | RXRA | P19793 | 1/20 | 0.38 |
| ▸ | RXRB | P28702 | 1/20 | 0.38 |
| ▸ | RXRG | P48443 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KIF11 | P52732 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9426486 | 0.85 | CHRM5 (0.52) | CHRM2CHRM1CHRM3CHRM4CHRM5 | |
| SCHEMBL13652111 | 0.85 | CHRM1 (0.44) | CHRM2CHRM1CHRM3CHRM4CHRM5 | |
| SCHEMBL9426585 | 0.84 | SIGMAR1 (0.52) | CHRM2CHRM1CHRM3CHRM4CHRM5 | |
| SCHEMBL9426230 | 0.82 | SIGMAR1 (0.46) | CHRM2CHRM1CHRM3CHRM4CHRM5 | |
| SCHEMBL9426893 | 0.82 | SIGMAR1 (0.46) | CHRM2CHRM1CHRM3CHRM4CHRM5 | |
| SCHEMBL9426759 | 0.82 | SIGMAR1 (0.46) | CHRM2CHRM1CHRM3CHRM4CHRM5 | |
| SCHEMBL9426658 | 0.82 | SIGMAR1 (0.46) | CHRM2CHRM1CHRM3CHRM4CHRM5 | |
| SCHEMBL9426654 | 0.82 | SIGMAR1 (0.37) | CHRM2CHRM1CHRM3CHRM4CHRM5 | |
| SCHEMBL9426928 | 0.81 | FDPS (0.50) | CHRM2CHRM1CHRM3CHRM4CHRM5 | |
| SCHEMBL9426661 | 0.81 | TRPM8 (0.46) | OPRM1DRD3DRD2DRD4ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5302595-A | Muscarinic receptor antagonists | PFIZER INC. (US) | 1994-04-12 | — | — | US | claimed |
| EP-0364123-B1 | MUSCARINIC RECEPTOR ANTAGONISTS | Pfizer Limited (GB) | 1991-06-12 | — | — | EP | claimed |
| EP-0364123-A1 | Muscarinic receptor antagonists | Pfizer Limited (GB) | 1990-04-18 | — | — | EP | claimed |
| US-5302595-A | Muscarinic receptor antagonists | PFIZER INC. (US) | 1994-04-12 | — | — | US | disclosed |
| US-5219871-A | MUSCARINIC RECEPTOR ANTAGONISTS | PFIZER INC. (US) | 1993-06-15 | — | — | US | disclosed |
| EP-0364123-B1 | MUSCARINIC RECEPTOR ANTAGONISTS | Pfizer Limited (GB) | 1991-06-12 | — | — | EP | disclosed |
| EP-0364123-A1 | Muscarinic receptor antagonists | Pfizer Limited (GB) | 1990-04-18 | — | — | EP | disclosed |